微小RNA功能与癌症形成的关联分析

China Animal Husbandry & Veterinary Medicine ›› 2008, Vol. 1 ›› Issue (2): 49-54.

• 遗传繁育 • Previous Articles Next Articles

Association Analysis between Function of miRNA and Formation of Cancer

BAO Adong3，2，1，LIU Changqing4，1，WU Hongmei1，LIU Shuai2，1，GUAN Weijun1,MA Yuehui1

1.Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100094, China;2.Inner Mongolia Agricultural University, Hohhot 010018, China;3. Farming-grazing Department, Hetao University, Linhe 015000, China;4.College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China

Received:1900-01-01 Revised:1900-01-01 Online:2008-02-20 Published:2008-02-20

Abstract

Abstract: MicroRNAs are small non-coding RNAs about 16~29 nucleotides in length that regulate gene expression at the post transcriptional level by silencing of target genes. It can cause degradation of target mRNA and inhibit the synthesis of protein in key time of cell degradation, development and apoptosis. Research has revealed that, miRNAs participate in formation, development and many cell signal pathways of malignant tumor as either oncogenes or tumor suppressors. Today the research on association analysis between function of miRNA and formation of cancer becomes a hotspot at home and abroad. This paper summarized the develop mechanism and biological function of miRNA. We also discussed on the major miRNAs related to cancer and gave a predict of diagnosis and treatment of cancer.

Key words: function of miRNA; formation of cancer; association analysis; therapy of cancer

CLC Number:

Q753

BAO Adong;;LIU Changqing;WU Hongmei;LIU Shuai;GUAN Weijun;MA Yuehui. Association Analysis between Function of miRNA and Formation of Cancer [J]. China Animal Husbandry & Veterinary Medicine, 2008, 1(2): 49-54.

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Association Analysis between Function of miRNA and Formation of Cancer

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