肺表面活性蛋白研究进展

摘要/Abstract

摘要： 肺表面活性蛋白是磷脂发挥功能的重要载体，主要分布于支气管表面和肺泡气—液界面，具有降低表面张力的特性，可防止肺泡塌陷，有利于气体交换，维持肺残气量和保持肺部的顺应性。目前已发现4种蛋白，分别是SP-A、SP-B、SP-C和SP-D。这4种蛋白在肺部疾病防御及肺功能的维持中起重要作用。因此，作者从SP的结构、功能及其与疾病的相关性方面进行综述，为今后的研究提供基础依据。

关键词: 肺表面活性蛋白; 结构; 功能; 疾病; 相关性

Abstract: Pulmonary surfactant protein （SP） is a carrier which plays an important role in phospholipids, mainly in the bronchial surface and alveolar gas-liquid interface, with lower surface tension properties, prevents alveolar collapse, is beneficial to gas exchange and to maintain the lungs pulmonary residual volume and to keep pulmonary compliance. Four kinds of proteins have been found, namely SP-A, SP-B, SP-C and SP-D. These four proteins in lung disease defensive and in maintaining lung function play important roles. Therefore, this article reviews SP from its structure, function and the correlation with the disease, to provide a basis for future research.

Key words: surfactant protein; structure; function; disease; correlation

孟庆雪,刘玉芬,刘静,吴迪. 肺表面活性蛋白研究进展[J]. 中国畜牧兽医.

MENG Qing-xue, LIU Yu-fen, LIU Jing, WU Di. Research Progress of Pulmonary Surfactant Proteins[J]. .

参考文献

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