细胞色素P450 2E1的研究进展

摘要/Abstract

摘要： 细胞色素P450 2E1(CYP2E1)是机体对药物和低分子化合物代谢的主要酶之一,且CYP2E1的活性增强或高表达与临床多种疾病密切相关。文章综述了国内外CYP2E1的蛋白结构、功能、定位机制及基因多态性等方面的研究进展。从而为进一步探索机体内CYP2E1的生物学效应及其与临床疾病的相关性奠定基础。

关键词: 细胞色素P450 2E1(CYP2E1); 蛋白结构; 功能; 基因多态性; 肝脏毒性

Abstract: Cytochrome P450 2E1 (CYP2E1) is one of the body's metabolite of drugs and low molecular weight compounds mainly enzymes, and the increasing of activity or expression of CYP2E1 is closely related with the clinical variety of diseases. This paper reviews the research progress of protein structure, function, positioning mechanism and other aspects of genetic polymorphisms of CYP2E1 at home and abroad. Thereby the paper could lay the foundation for further exploration of the biological effects of CYP2E1 and its relationship with clinical disease.

Key words: cytochrome P450 2E1 (CYP2E1); protein structure; function; gene polymorphism; liver toxicity

中图分类号:

R963

武淑琴, 王成双, 王新, 李鹏. 细胞色素P450 2E1的研究进展[J]. , 2014, 41(11): 165-170.

WU Shu-qin, WANG Cheng-shuang, WANG Xin, LI Peng. Research Progress on Cytochrome P450 2E1[J]. , 2014, 41(11): 165-170.

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