›› 2008, Vol. 1 ›› Issue (8): 32-35.

• 生理生化 • 上一篇    下一篇

脑源性神经营养因子研究进展

刘燕1,荀来武2,王桂瑛1   

  1. 1.云南农业职业技术学院, 昆明 650212; 2.云南省种畜场奶牛分场, 昆明 650212
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2008-08-20 发布日期:2008-08-20

Recent Advances in Brain Derived Neurotrophic Factor

LIU Yan1, XUN Lai-wu2, WANG Gui-ying1   

  1. 1.Department of Animal Husbandry and Veterinary, Yunnan Agricultural Vocational Technical College, Kunming 650212, China; 2.Dairy Farm of Yunnan Province Livestock Breeding Station, Kunming 650212,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2008-08-20 Published:2008-08-20

摘要: 脑源性神经营养因子是一种小分子二聚体蛋白质,在结构上与神经生长因子相关,对中枢神经系统的多种类型神经元的生长、发育、分化、维护和再生都具有重要作用,对于治疗运动神经元病变及神经系统进行性疾病有显著疗效。作者对其细胞与分子生物学特征、生物学功能进行阐述。

关键词: 脑源性神经营养因子; 结构; 功能

Abstract: Brainderived neurotrophic factor (BDNF) is a small dimmeric protein, structurally related to nerve growth factor. which is abundantly and widely expressed in the adult mammalian brain. BDNF plays an important role in the growth, development, differentiation, maintenance and regeneration of various types of neurons in the CNS and has potential application to the treatment of brain injury and neurodegenerative diseases. In this paper, the molecular and cellular biology and potential clinical application of BDNF were reviewed.

Key words: brainderived neurotrophic factor; structure; function

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