中性粒细胞细胞外诱捕网的研究进展

doi:10.16431/j.cnki.1671-7236.2018.01.026

Abstract

Abstract:

Neutrophils,which have become the largest number of immune cells in the peripheral blood,are the important components of the innate immune system in the body and which constitute the first line of defensing against microbial invasion, playing an important role in nonspecific immunity. Besides of the classic phagocytosis of pathogens, degranulation and the release of bactericidal substances, it is found that neutrophils have a new mechanism——Neutrophil extracellular traps (NETs), which could resist the microbial invasion in recent years. Because of the reactive oxygen,peptidylated arginine deaminase 4 and other factors, neutrophils is formed of traps with DNA as the skeleton of the network structure and containing a variety of proteases. NETs can capture and kill pathogens nonspecifically and also play a synergistic role in the production and deterioration of certain diseases. This article is an overview on the formation of NETs,influencing factors and the relationship between NETs and pathogens or diseases to provide the references for studying the function of neutrophils.

Key words: polymorphonuclear neutrophil; neutrophil extracellular traps (NETs); reactive oxygen; disease

CLC Number:

R392.1

ZHANG Kai, CHEN Hongyu, LI Jiao, BAO Li, DUAN Ping, JIANG Ning. Research Progress on Neutrophil Extracellular Traps[J]. , 2018, 45(1): 206-211.

References

[1] BRINKMANN V,REICHARD U,GOOSMANN C, et al.Neutrophil extracellular traps kill bacteria[J]. Science,2004,303(5663):1532-1535.
[2] CONTIS-MONTES DE OCA A, CARRASCO-YÉPEZ M, CAMPOS-RODRÍGUEZ R, et al.Neutrophils extracellular traps damage Naegleria fowleri trophozoites opsonized with human IgG[J]. Parasite Immunology,2016, 38(8):481-495.
[3] BAUMS C G,VON KÖCKRITZ-BLICKWEDE M. Novel role of DNA in neutrophil extracellular traps[J]. Trends in Microbiology,2015,23(6):330-331.
[4] FATTAHI F,GRAILER J J,JAJOU L,et al.Organ distribution of histones after intravenous infusion of FITC histones or after sepsis[J]. Journal of Immunology Research,2015,61(3):177-186.
[5] BUCHANAN J T, SIMPSON A J, AZIZ R K, et al.DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps[J]. Current Biology,2006,16(4):396-400.
[6] URBAN C F,REICHARD U,BRINKMANN V,et al.Neutrophil extracellular traps capture and kill Candida albicans yeast and hyphal forms[J]. Cellular Microbiology, 2006,8(4):668-676.
[7] ANDREW H, ROSS C, GABRIELA G, et al.Natural product anacardic acid from cashew nut shells stimulates neutrophil extracellular trap production and bactericidal activity[J]. Journal of Biological Chemistry,2016,291(27):13964-13973.
[8] FUCHS T A,ABED U,COOSMANN C, et al.Novel cell death program leads to neutrophil extracellular traps[J]. Cell Biology,2007,176(2):231-241.
[9] BJÖRNSDOTTIRA H, WELIN A, MICHAěLSSON E,et al.Neutrophil NET formation is regulated from the inside by myeloperoxidase-processed reactive oxygen species[J]. Free Radical Biology and Medicine,2015,89:1024-1035.
[10] ROCHAEL N C, GUIMARAES-COSTA A B,NASCIMENTO M T, et al.Classical ROS-dependent and early/rapid ROS-independent release of neutrophil extracellular traps triggered by Leishmania parasites[J]. Scientific Reports,2015,5:18302-18313.
[11] NISHINAKA Y,ARAI T,ADACHI S, et al.Singlet oxygen is essential for neutrophil extracellular trap formation[J]. Biochemical and Biophysical Research Communications,2011,413(1):75-79.
[12] ARAI Y, NISHINAKA Y, ARAI T, et al.Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation[J]. Biochemical and Biophysical Research Communications,2014,443(2):556-561.
[13] YU B P.Cellular defenses against damge from reactive oxygcn species[J].Physiological Reviews, 1994,74(1):139-162.
[14] KENNO S,PERITO S,MOSCI P, et al.Autophagy and reactive oxygen species are involved in neutrophil extracellular traps release induced by C. albicans morphotypes[J]. Frontiers in Microbiology, 2016,7:879.
[15] WANG Y, LI M,STADLER S, et al.Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation[J]. Cell Biology,2009,184(2):205-213.
[16] LI P, LI M, LINDBERG M R, et al.PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps[J]. Journal of Experimental Medicine,2014,207(9):1853-1862.
[17] REMIJSEN Q,VANDEN BERGHE T, WIRAWAN E, et al.Neutrophil extracellular trap cell death requires both autophagy and superoxide generation[J].Cell Research,2011,21(2):290-304.
[18] 黄鑫,高雪静,王渊, 等.分子伴侣性自噬参与LAMP-2抗体诱导中性粒细胞胞外捕网形成[J]. 免疫学杂志,2015,31(30):185-189. HUANG X,GAO X J,WANG Y, et al.Chaperone-mediated autophagy participates in anti-LAMP-2 antibody-induced neutrophil extracellular trap formation[J].Immunological Journal, 2015, 31(30):185-189.(in Chinese)
[19] PILSCZEK F H, SALINA D, POON K K H, et al.A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aur-eus[J]. Journal of Immunology, 2010, 185(12):7413-7425.
[20] CHANG Z, JIANG N, ZHANG Y, et al. The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate[J]. Nature Communications,2016,7(5):11537-11546.
[21] JEFFERY U, KIMURA K, GRAY R, et al.Dogs cast NETs too:Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia[J]. Veterinary Immunology and Immunopathology,2015, 168(3/4):262-268.
[22] 朱鏐娈,张玥,李国力, 等.建立体外诱导和检测中性粒细胞胞外诱捕网的方法[J]. 中华实验和临床感染病杂志,2015,9(3):405-408. ZHU M L, ZHANG Y,LI G L, et al.Establishment of the methods of inducing and detecting neutrophil extracellular trap in vitro[J]. Chinese Journal of Experimental and Clinical Infectious Disease, 2015, 9(3):405-408.(in Chinese)
[23] BFINKMANN V,ZYCHLINSKY A.Beneficial suicide:Why neutrophils die to make NETs[J]. Nature Reviews Microbiology,2007,5(8):577-582.
[24] Marques C S, Passero L F, Vale-Gato I, et al.New insights into neutrophil and Leishmania infantum in vitroimmune interactions[J]. Microbiology and Infectious Diseases, 201540(6):19-29.
[25] BEHRENDT J H, RUIZ A, ZAHNER H, et al.Neutrophil extracellular trap formation as innate immune reactions against the apicomplexan parasite Eimeria bovis[J]. Veterinary Immunology and Immunopathology, 2010, 133(1):1-8.
[26] JON H, PHILLIPA H, IAIN L C, et al.Impaired neutrophil extracellular trap formation:A novel defect in the innate immune system of aged individuals[J]. Aging Cell,2014,13(4):690-698.
[27] 庄利利,胡德宝,蔡丽娟, 等.哺乳动物胚胎的活性氧来源及其抗氧化机制[J]. 中国畜牧兽医, 2013, 40(3):173-176. ZHUANG L L,HU D B,CAI L J, et al.Rossorces and anti-oxidative mechannismsin mammalian embryos[J]. China Animal Husbandry & Veterinary Medicine,2013,40(3):173-176.(in Chinese)
[28] CHI H,CHU L.Neutrophils of Scophthalmus maximus produce extracellular traps that capture bacteria and inhibit bacterial infection[J]. Developmental and Comparative Immunology,2016,56:7-12.
[29] CLARK S R,MA A C,TAVENER S A, et al.Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood[J].Nature Medicine,2007,13(4):463-469.
[30] SORENSEN O E, BORREGAARD N. Neutrophil extracellular traps——The dark side of neutrophils[J]. The Journal of Clinical Investigation,2016,126(5):1612-1620.
[31] KHANDPUR R,CARMONA R C,VIVEKANADAN G A, et al.NETs are a source of citrullinated autoantigens and stimulate inflammatory response in rheumatoid arthritis[J]. Science Translational Medicine, 2013, 5(178):178ra40.
[32] MARKO R,TONY N M. Neutrophil extracellular chromatin traps connect innate immune response to autoimmunity[J]. Seminars in Immunopathology,2013,35(4):465-480.
[33] STORISTEANU D M, POCOCK J M, COWBURN A S, et al.Evasion of neutrophil extracellular traps by respiratory pathogens[J]. American Journal of Respiratory Cell and Molecular Biology,2017,56(4):423-431.
[34] GONDAIRA S, HIGUCHI H, NISHI K, et al.Mycoplasma bovis escapes bovine neutrophil extracellular traps[J]. Veterinary Microbiology,2017,199:68-73.
[35] GUIMARÃES-COSTA A B, DESOUZA-VIEIRA T S, PALETTA-SILVA R, et al.3'-nucleotidase/nuclease activity allows Leishmania parasites to escape killing by neutrophil extracellular traps[J]. Infection and Immunity, 2014, 82(4):1732-1740.
[36] BEITER K, WARTHA F, ALBIGER B, et al. An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps[J]. Current Biology,2006,16(4):401-407.
[37] JONOHNSON C J, CABEZAS O J,KERNIEN J F,et al. The extracellular matrix of Candida albicans biofilms impairs formation of neutrophil extracellular traps[J]. PLoS Pathogens,2016,12(9):e1005884.
[38] LEE W L, GRINSTEIN S. The tangled webs that neutrophils weave[J]. Science,2004, 303(5663):1477-1478.
[39] WALKER T S, TOMLIN K L, WORTHEN G S, et al. Enhanced Pseudomonas aeruginosa biofilm development mediated by human neutrophils[J]. Infection and Immunity,2005,73(6):3693-3701.
[40] VOROBJEVA N V,PINEGIN B V. Effects of the antioxidants Trolox, Tiron and Tempol on neutrophil extracellular trap formation[J]. Immunobiology,2016,37(3):143-149.

Research Progress on Neutrophil Extracellular Traps

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LYU Chunrong, LIANG Jiachong, SHAO Qingyong, WU Guoquan, ZHANG Yumei, QUAN Guobo. Effects of Sodium Pyruvate on the Quality of Frozen Goat Sperm [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2363-2369.
[2]	CAO Qi, JIN Qing, YUAN Yi, FENG Yixue, KONG Danni, CHEN Xianghong, WU Bin, SONG Wenbo, TANG Xibiao. Epidemiological Investigation of Common Respiratory Bacterial Pathogens in Large-scale Pig Farms [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2439-2449.
[3]	LI Mingguo, LI Qingchun, CHEN Xin, LU Shihao, HE Fan, QI Mengfan, ZHANG Huapeng, REN Yujun, ZHANG Qingze, FU Binbin, XU Mengsi, AI Zikai, YAN Kun, FENG Yun, HUA Zaidong, HUANG Tao, BI Yanzhen. Effects of TET Demethylase on Porcine Oocyte Development [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1907-1917.
[4]	WANG Zeping, WANG Feifei, ZHANG Ruiming, FU Yanfeng, ZHAO Weimin, DAI Chaohui, CHENG Jinhua, LIAO Chao, LI Hui. Analysis on Polymorphism of SLA-1 Gene and Its Disease Resistance Potential in Suzi Pig [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1918-1927.
[5]	SUN Yanyong, MA Fengying, GUO Lili, LIU Zaixia, LIU Bin, ZHANG Wenguang, LIU Yongbin. Advances on the Application of Animal Blood Transcriptome [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 460-468.
[6]	ZHENG Xiaohui, LIU Kun, XIN Hangkuo, XIE Qingqing, ZHU Ting. Advance in the Regulation of Mitophagy in Neurodegenerative Diseases [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 490-499.
[7]	HE Yue, WANG Hui, CHEN Ruipeng, YU Zhixue, TANG Xiangfang, GUO Yuming, XIONG Benhai. Research Progress on Optical and Electrochemical Biosensors for the Diagnosis of Important Diseases in Dairy Cows [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 827-837.
[8]	SONG Peijia, JIN Yipeng, LIN Degui, LIN Jiahao. Clinical Research Progress on Canine Periodontal Diseases [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 838-845.
[9]	LI Shangru, SONG Jiamei, ZHANG Chengrui, SUN Yukun, ZHANG Yonggen. Study on Dairy Cow Disease Prediction Model Based on Machine Learning Algorithm [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(7): 2534-2546.
[10]	HOU Wei. Research Progress on Construction of Phage Display System and Its Application in the Field of Disease Prevention and Control [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1688-1696.
[11]	XU Jing, YANG Guang, JIANG Meiqi, DING Xiangbin, GUO Yiwen, HU Debao, LI Xin, GUO Hong, ZHANG Linlin. Research Advances on CRISPR/Cas9 Technology in Livestock and Poultry Breeding [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1374-1383.
[12]	CHI Shanshan, JIA Weijuan, HE Yunjiang, MENG Qinglei, CHEN Yunjiao, WANG Xueli. Research Progress on Newcastle Disease Virus-like Particles [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1507-1515.
[13]	ZHAO Tianrui, SHAO Jinhua, WANG Chaohao, YAN Rui, LEI Yifei, LIU Xiaoya, HU Changmin. Isolation and Identification of Skin Pathogenic Bacteria from Dogs and Cats and Analysis of Antibacterial Effect of Natural Products [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1556-1567.
[14]	FANG Qianhai, CHEN Hongbo, BI Yanzhen. Research Progress on Important Breeding Value Genes and Screening Techniques of Pigs [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 992-1004.
[15]	HE Xianming, REN Guangcai, YE Junxian, LAN Hong, LIU Yufu, XIONG Ting, YANG Zekun, XU Ting, CHEN Ruiai. Isolation and Identification of a Strain of Infectious Bursal Disease Virus and Sequence Analysis of VP2 Gene [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(3): 1005-1014.