线粒体自噬在神经退行性疾病中调控的研究进展

doi:10.16431/j.cnki.1671-7236.2023.02.007

Abstract

Abstract: Neurodegenerative disease is a central nervous system disease based on the progressive degeneration and necrosis of neurons,which is commonly characterized by the accumulation of misfolded proteins and mitochondrial damage.As the center of cellular energy production,mitochondria are the main energy source of neurons and are essential for maintaining the structure and function of neurons.Damaged mitochondria lead to inadequate ATP supply and oxidative stress damage,and even resulte in cellular death.Mitophagy is a process by which cells selectively remove senescent or damaged mitochondria through the autophagy-lysosome pathway.It is an important part of mitochondrial quality control mechanism and plays an important role in maintaining cellular homeostasis.Many studies have suggested that mitophagy is closely related to the occurrence and development of neurodegenerative diseases.Activation of mitophagy or improvement of mitophagy abnormalities can alleviate neuronal damage caused by misfolded protein accumulation.In this paper,the author reviewed the mechanism of mitophagy,its regulation and its role in the occurrence and development of neurodegenerative diseases,which was in order to provide reference for the research and treatment of neurodegenerative diseases.

Key words: neurodegenerative diseases; mitochondria; mitophagy; neuronal damage

CLC Number:

S852.3

ZHENG Xiaohui, LIU Kun, XIN Hangkuo, XIE Qingqing, ZHU Ting. Advance in the Regulation of Mitophagy in Neurodegenerative Diseases[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 490-499.

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Advance in the Regulation of Mitophagy in Neurodegenerative Diseases

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