线粒体动力学平衡对心脏结构与功能的影响

doi:10.16431/j.cnki.1671-7236.2020.03.009

Abstract

Abstract: The heart is an organ that consumes a lot of energy and oxygen,its normal contraction and normal transmission of electrical signals also need a lot of energy supply,so cardiomyocytes contain a large number of mitochondria.Under normal physiological conditions,the number,morphology and function of mitochondria in cells are relatively stable.When the energy production of cells in the body is insufficient or there are different defects in two independent mitochondria,the mitochondria will fuse under the regulation of Mfn1/2 and OPA1.After fusion,the content of mitochondrial matrix mixes with each other to form a new mitochondrion with perfect function,which is called mitochondrial fusion.In order to maintain the stability of mitochondrial DNA and mitochondrial membrane potential,mitochondria divide under the regulation of Drp1 and its receptors.Division can make damaged mitochondrial DNA and depolarized mitochondrial membrane aggregate into one daughter mitochondrion during division.And it can be eliminated by ubiquitination protease system or autophagy to maintain the normal function of mitochondria.Mitochondrial fusion and division is a continuous fluctuating process,which has been considered to be the key process to maintain the normal function and morphology of mitochondria and cells.In recent years,it has been found that the imbalance of mitochondrial fusion and division in cardiomyocytes will lead to the disorder of their own morphology and function,and then damage the structure and function of the heart.Therefore,maintaining the homeostasis of cardiomyocytes requires the dynamic balance between mitochondrial division and fusion,while maintaining the dynamic balance of mitochondria needs to mediate mitochondrial fusion and division related dynamic proteins.In this paper,the functions of key proteins involved in mitochondrial fusion and division were reviewed,and the effects of mitochondrial dynamic balance on cardiac structure and function were discussed,which would provide a theoretical basis for later research.

Key words: cardiac; mitochondrial; mitochondrial dynamics; fusion; division

CLC Number:

Q255

CUI Yunli, SONG Xiaochao, CHEN Lingli, GE Yaming, NING Hongmei, HU Dongfang. Effects of Mitochondrial Dynamics Balance on Cardiac Structure and Function[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(3): 722-728.

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Effects of Mitochondrial Dynamics Balance on Cardiac Structure and Function

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