长链非编码RNA及其在医学、家畜方面的研究进展

›› 2012, Vol. 39 ›› Issue (12): 55-60.

长链非编码RNA及其在医学、家畜方面的研究进展

李托, 徐华荣, 王昕

西北农林科技大学动物科技学院, 陕西杨凌 712100

收稿日期:2012-05-17 出版日期:2012-12-20 发布日期:2012-12-19
通讯作者: 王昕,女,山东人,博士,副教授。E-mail:wxwza@126.com E-mail:wxwza@126.com
作者简介:李托(1986-),女,陕西人,硕士,研究方向:生物技术与动物育种。
基金资助:
国家自然基金青年科学基金项目(31201769)。

Research Progress on Medical Science and Livestock of Long non-coding RNA

LI Tuo, XU Hua-rong, WANG Xin

College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Received:2012-05-17 Online:2012-12-20 Published:2012-12-19

摘要/Abstract

摘要： 长链非编码RNA(long non-coding RNA, LncRNA)是一类转录本长度超过200 nt的RNA分子,没有或少有编码蛋白的能力。LncRNA参与编码基因表达调控的表观遗传机制,能够直接调控靶基因的转录与蛋白的降解等,在基因组印记、转录调控及人类疾病等方面有着广泛功能。作者着重对LncRNA的特点、分类、作用机制及其在医学和家畜方面的研究进展作一综述,最后对LncRNA在家畜方面的研究与应用进行展望。

关键词: 长链非编码RNA; 转录调节; 人类疾病; 家畜育种; 功能

Abstract: Long non-coding RNA (LncRNA) is a functional RNA segment longer than 200 nucleotides, with little or no protein-coding capacity and can be transcribed in most eukaryotic genome. LncRNAs are involved in epigenetic mechanism regulating the transcription of targeting gene and associated with genomic imprinting, transcription regulation and human diseases. This paper reviews the characteristics, classify, molecular mechanisms and current research efforts on medical science and livestock of LncRNAs. Finally, we prospect the application of LncRNAs in domestic animal.

Key words: long non-coding RNA; transcriptional regulation; human disease; livestock breeding; function

中图分类号:

Q527

李托, 徐华荣, 王昕. 长链非编码RNA及其在医学、家畜方面的研究进展[J]. , 2012, 39(12): 55-60.

LI Tuo, XU Hua-rong, WANG Xin. Research Progress on Medical Science and Livestock of Long non-coding RNA[J]. , 2012, 39(12): 55-60.

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