纳米铜对大鼠肝脏毒性的蛋白质组2-DE图谱分析

Abstract

Abstract: In order to obtain protein expression map of nanoparticles copper(nano-copper) toxicity in rat liver, this study constructed the model of the nano-copper in rats, and obtained 2-DE maps of nano-copper toxicity in rats group and control group used by two-dimensional gel electrophoresis technique, PDQuest 8.0 analysis showed that the total 43 protein spots significantly differently expressed in rat liver of 200 mg/kg copper nanoparticles group which 27 spots were up and 16 spots were down. The toxicity of nano-copper in rats liver was studied by proteomics approach in the paper, the results would establish the foundation for clarifying the mechanism of the toxic effects of nano-copper at protein level.

Key words: proteomics; 2-DE; nanoparticles copper; rat

CLC Number:

GAO Zhao-hui, DONG Shu-wei, XUE Hui-wen, SHEN Xiao-yun, LI Xia. 2-DE Map Analysis of Proteomics in Rat with the Hepatotoxic Mechanisms of Nanoparticles Copper[J]. , 2012, 39(11): 22-26.

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2-DE Map Analysis of Proteomics in Rat with the Hepatotoxic Mechanisms of Nanoparticles Copper

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