柏芩提取液的药效学及对奶牛子宫内膜炎的疗效评价

doi:10.16431/j.cnki.1671-7236.2020.05.037

Abstract

Abstract: Baiqin extract is composed of Phellodendron chinense,Scutellaria baicalensis,Carthamus tinctorius,Codonopsis pilosula,etc.In order to investigate its therapeutic effect against cow endometritis,the main pharmacodynamics was studied by using experimental rabbit model of endometritis.Besides,the clinical efficacy was evaluated according to the 'Guideling principles for the safety and efficacy test of antimicrobial veterinary drugs for the prevention and treatment of clinical endometritis in dairy cattle' which was issued by the Ministry of Agriculture and Rural Affairs of the People's Republic of China.The results of the pharmacodynamic experiments revealed that Baiqin extract could obviously improve the clinical symptoms of experimental endometritis in rabbits as compared to model group.It has been examined that differential leukocyte counting,uterus secretion smear microscopy,chemical examination of urine and uterus secretion were returned to normal,and abnormal histopathological changes of uterus such as hyperemia,inflammatory cells infiltrates and shedding of epithelial cells were partially alleviated in the uterus of rabbits.Clinical efficacy results showed that at 10th day after administration,the curative rates against endometritis in the high- and medium-dose groups of Baiqin extract were extremely significantly higher than that in the low-dose group (P<0.01),and were no significant difference compared with the positive drug group (P>0.05);While there was no significant difference in the total effective rates among all the tested groups (P>0.05).On 21st day post-treatment,the curative rates in the high- and medium-dose groups of Baiqin extract were significantly higher than that in the low-dose group (P<0.05),and were no significant difference compared with the positive drug group (P>0.05);While there was no significant difference in the total effective rates among all the tested groups (P>0.05).These results indicated that Baiqin extract had a good therapeutic effect on rabbit experimental endometritis and cow clinical endometritis,and the therapeutic efficacy of 1.5 or 1.0 g/mL concentration (30 mL at a time) on clinical cases was excellent,and similar with that of oxytetracycline,the therapeutic efficacy of 0.5 g/mL was non-obvious.The study would lay a foundation for further research and development.

Key words: Baiqin extract; endometritis; anti-inflammatory action; pharmacodynamics; clinical efficacy

CLC Number:

S858.31

QIAN Feng, MIAO Yusong, MUHAMMAD Ishfaq, YIN Peng, YIN Jianli, LI Jichang. Pharmacodynamics of Baiqin Extract and Clinical Efficacy Evaluation for Treatment of Cow Endometritis[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(5): 1618-1627.

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Pharmacodynamics of Baiqin Extract and Clinical Efficacy Evaluation for Treatment of Cow Endometritis

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