莫西菌素在畜牧业中的应用研究进展

doi:10.16431/j.cnki.1671-7236.2018.12.033

Abstract

Abstract:

Moxidectin (MOX) is derived from derivatization of nemadectin produced by Streptomyces (Cyanneogrisens noncyanogenus),which has good insect repellent activity and is safe for mammals,and it is mainly used in animal husbandry.Moxidectin has better fat-soluble and water-soluble than other avermectin drugs,and has the highest distribution in adipose tissues of animals.Moxidectin binds to GABA,and neural membrane potential hyperpolarization is caused by massive influx of Cl^-,resulting in the death due to the insect's body paralysis.Differences in the route of administration and the physiological condition of animals would affect the peak concentration and depletion half-lives.Moxidectin has good insect repellent activity in animals such as cattle,sheep and dogs.The application range of moxidectin gradually expands from mammals to birds,and the control objects gradually extend from nematodes to mite and several kinds of germs.The research direction extends from anthelmintic activity to the treatment of human diseases.With the increase of the application range of moxidectin and the prolongation of time,the drug resistance began to appear,and the rate of drug resistance could be reduced by the combination of moxidectin and other agents.Exploring the wider role of moxidectin requires the efforts of researchers in different fields.

Key words: moxidectin; pharmacokinetics; pharmacodynamics; drug resistance

CLC Number:

S859.79⁺5

LI Jiao, LI Qingshan, XU Fengbo. Research Progress of Moxidectin in Animal Husbandry[J]. , 2018, 45(12): 3587-3593.

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Research Progress of Moxidectin in Animal Husbandry

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