兽用头孢菌素类抗生素研究进展

doi:10.16431/j.cnki.1671-7236.2018.07.032

Abstract

Abstract:

Cephalosporins are known for their broad spectrum and strong antibacterial activity in clinic.Cephalosporins are widely used in the medical field, but their application is partly restricted in veterinary medicine because of fewer classes,and cross resistance derived from abusing and misusing.Therefore,the review concluded the development process of cephalosporin, antibacterial mechanism, pharmacokinetics and safety, summarized the main classes of veterinary cephalosporin, antibacterial activity and pharmacokinetic parameters in animals, compared the antibacterial activity of the main veterinary cephalosporin and the therapeutic effect on sensitive bacterial infection diseases.Meanwhile,the resistance mechanism and the situation of resistance of cephalosporin were summarized, and the measures taken by various countries on the resistance control were compared and analyzed.Through the review of the development and clinical application of veterinary cephalosporin,it was made for promoting the scientific and standardized use of cephalosporin in benefit clinic.

Key words: veterinary cephalosporin; pharmacodynamics; pharmacokinetics; adverse effect; resistance

CLC Number:

S859.79⁺6

LI Mei, SUN Lingling, YUAN Zonghui, HUANG Lingli. Research Progress on Veterinary Cephalosporins[J]. , 2018, 45(7): 1978-1989.

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Research Progress on Veterinary Cephalosporins

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