Fosl2基因的研究进展

中国畜牧兽医

Fosl2基因的研究进展

范兴兴，李新建，郭吉利，李改英，吕刚，任广志

河南农业大学牧医工程学院，河南郑州 450000

收稿日期:2014-02-07 出版日期:2014-08-20 发布日期:2014-08-22
通讯作者: 任广志（1955—），男，教授，研究方向：猪遗传育种与繁殖。E-mail：rgzhxt@163.com
作者简介:范兴兴（1988—），女，河南人，硕士，研究方向：动物遗传育种与繁殖。
基金资助:
河南省重大科技专项资金资助（111100110300）；河南省生猪产业技术体系创新团队（S2012-06）。

Research Progress of Fosl2 Gene

FAN Xing-xing, LI Xin-jian, GUO Ji-li, LI Gai-ying, LV Gang, REN Guang-zhi

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China

Received:2014-02-07 Online:2014-08-20 Published:2014-08-22

摘要/Abstract

摘要： Fosl2(Fos-like antigen 2)属于活化因子蛋白1(activator protein-1,AP1)转录因子家族中的一种，在多种组织中均有显著表达，对哺乳动物的生长发育、生殖性状、免疫应答等起到重要的作用。近年来，随着研究的深入，人们发现Fosl2基因与脂肪代谢、骨骼发育及疾病和癌症的发生有着重要联系。作者综述了Fosl2基因的结构与组织表达分布，同时概述了其在脂肪代谢、骨骼发育、癌症发生及眼部发育等重要生理过程中的作用，并对其生物功能进行了展望，以期为更深层次的研究和提高动物的生长发育性状提供参考。

关键词: Fosl2基因; 组织表达与结构; 脂肪代谢; 骨骼发育; 生物学功能

Abstract: Fosl2 (Fos-like antigen 2) that is expressed in a wide range of tissues during animal development belongs to the activator protein-1(AP1) transcription factor family that includes the various isoforms of Fos and Jun, which play diverse and important roles in animal growing development and immunologic response. Following the indepth research of recent years, people found that Fosl2 has a very close relationship with animal fat metabolism, skeleton development and cancer growth. This article reviewed the gene structure and the tissue distribution, also generalized the function of Fosl2 in animal fat metabolism, skeleton development, cancer growth and eye development. The prospects in study on the biological function were discussed in order to show a clearly direction for the deeper study and the animal growth traits promotion.

Key words: Fosl2 gene; tissue expression and gene structure; fat metabolism; skeleton development; biological function

范兴兴，李新建，郭吉利，李改英，吕刚，任广志. Fosl2基因的研究进展[J]. 中国畜牧兽医.

FAN Xing-xing, LI Xin-jian, GUO Ji-li, LI Gai-ying, LV Gang, REN Guang-zhi. Research Progress of Fosl2 Gene[J]. .

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