[1] FAIRBROTHER J M,NADEAU E,GYLES C L. Escherichia coli in postweaning diarrhea in pigs:An update on bacterial types,pathogenesis,and prevention strategies[J].Animal Health Research Reviews,2005,6(1):17-39. [2] RHOUMA M,FAIRBROTHER J M,BEAUDRY F,et al.Post weaning diarrhea in pigs:Risk factors and non-colistin-based control strategies[J].Acta Veterinaria Scandinavica,2017,59:31. [3] ANDREA L.Swine enteric colibacillosis:Diagnosis,therapy and antimicrobial resistance[J].Porcine Health Management,2017,3:16 [4] 吴文文,丁雪燕,洪天旗,等.猪源产肠毒素性大肠杆菌主要毒力因子研究进展[J].中国兽医学报,2019,39(7):1403-1409. WU W W,DING X Y,HONG T Q,et al.Research progress on the main virulence factors of enterotoxin-producing Escherichia coli from pigs[J].Chinese Journal of Veterinary Science,2019,39(7):1403-1409.(in Chinese) [5] 蒋磊,周明旭,夏芃芃,等.产肠毒素大肠杆菌感染的分子致病机制[J].中国兽医学报,2014,34(9):1551-1560. JIANG L,ZHOU M X,XIA P P,et al.Molecular pathogenic mechanisms of enterotoxigenic Escherichia coli infection[J].Chinese Journal of Veterinary Science,2014,34(9):1551-1560.(in Chinese) [6] 任敏敏,徐娥,申露露,等.产肠毒素大肠杆菌致使仔猪腹泻致病机理的研究进展[J].浙江畜牧兽医,2019,44(5):12-16. REN M M,XU E,SHEN L L,et al.Research progress on pathogenic mechanism of piglet diarrhea caused by enterotoxigenic Escherichia coli[J].Zhejiang Journal Animal Science and Veterinary Medicine,2019,44(5):12-16.(in Chinese) [7] QIAN X,ZHAO J,YEUNG P Y,et al.Revealing lncRNA structures and interactions by sequencing-based approaches[J].Trends in Biochemical Sciences,2019,44(1):33-52. [8] CHARLES R J L,EICHHORN P J A.Platforms for investigating lncRNA functions[J].SLAS Technology,2018,23(6):493-506. [9] FERRE F,COLANTONI A,HELMER-CITTERICH M.Revealing protein-lncRNA interaction[J].Briefings in Bioinformatics,2016,17(1):106-116. [10] CHEN J,ZHANG C,ZHANG N,et al.Porcine endemic diarrhea virus infection regulates long noncoding RNA expression[J].Virology,2019,527:89-97. [11] 刘炜玮.新城疫病毒感染鸡胚成纤维细胞的mRNAs和lncRNAs的研究[D].北京:中国农业科学院,2018. LIU W W.Analysis of mRNAs and lncRNAs in the chicken embryo fibroblasts on NDV infection[D].Beijing:Chinese Academy of Agricultural Sciences,2018.(in Chinese) [12] 甘利鹏,张婧,孙普,等.lncRNA TCONS_00179042对Marc-145细胞中PRRSV复制的影响[J].中国兽医科学,2018,48(5):537-544. GAN L P,ZHANG J,SUN P,et al.Effect of lncRNA TCONS_00179042 on the replication of Porcine reproductive and respiratory syndrome virus in Marc-145 cells[J].Chinese Veterinary Science,2018,48(5):537-544.(in Chinese) [13] YAN Z,HUANG X,SUN W,et al.Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by Clostridium perfringens type C[J].PeerJ,2018,6:e5997. [14] 赵宁.产肠毒素性大肠杆菌感染小鼠致腹泻lncRNA表达谱的构建[D].银川:宁夏大学,2016. ZHAO N.lncRNA expression signatures in response to enterotoxigenic Escherichia coli infection in mice[D].Yinchuan:Ningxia University,2016.(in Chinese) [15] 吴正常.断奶仔猪F18大肠杆菌抗性基因和lncRNA的筛选与调控机制分析[D].扬州:扬州大学,2017. WU Z C.Screening and regulatory mechanism analysis of genes and long noncoding RNA (lncRNA) related to E.coli F18 resistance in weaned piglets[D].Yangzhou:Yangzhou University,2017.(in Chinese) [16] ROBINSON M D,MCCARTHY D J,SMYTH G K.EdgeR:A bioconductor package for differential expression analysis of digital gene expression data[J].Bioinformatics,2010,26(1):139-140. [17] ENRIGHT A J,JOHN B,GAUL U,et al.microRNA targets in Drosophila[J].Genome Biology,2003,5(1):R1. [18] WU H J,MA Y K,CHEN T,et al.PsRobot:A web-based plant small RNA meta-analysis toolbox[J].Nucleic Acid Research,2012,40(Web Server issue):W22-8. [19] MATTHEW D Y,MATTHEW J W,GORDON K S,et al.Gene ontology analysis for RNA-seq:Accounting for selection bias[J].Genome Biology,2010,11(2):R14. [20] MAO X,CAI T,OLYARCHUK J G,et al.Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary[J].Bioinformatics,2005,21(19):3787-3793. [21] 周虹,朱军,朱国强.动物源产肠毒素大肠杆菌(ETEC)黏附素研究进展[J].微生物学报,2012,52(6):679-686. ZHOU H,ZHU J,ZHU G Q.Research progress of enterotoxigenic Escherichia coli (ETEC) adhesins from animals[J].Acta Microbiologica Sinica,2012,52(6):679-686.(in Chinese) [22] 季华员.猪产肠毒素型大肠杆菌F41受体基因的精细定位与鉴别[D].南昌:江西农业大学,2011. JI H Y.Fine mapping and genetic identification of the gene encoding the enterotoxigenic Escherichia coli F41 receptor[D].Nanchang:Jiangxi Agricultural University,2011.(in Chinese) [23] PYSZ M A,HAO F,HIZLI A A,et al.Differential regulation of cyclin D1 expression by protein kinase C α and ε signaling in intestinal epithelial cells[J].The Journal of Biological Chemistry,2014,289(32):22268-22283. [24] JIANG Z,LI L,HOU L,et al.Mechanism of protective effect of carnosol on pig intestinal epithelial cells[J].International Journal of Clinical and Experimental Pathology,2020,13(3):447-455. [25] RYU O,KIYOSHI T.Roles of intestinal epithelial cells in the maintenance of gut homeostasis[J].Experi-mental & Molecular Medicine,2017,49(5):e338. [26] RYU O,TOSHIO K,CHIAO-CHING H,et al.Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia[J].Mucosal Immunology,2020,13(1):75-85. [27] RYU O,TAKASHI K,TAKASHI N,et al.Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia[J].Nature,2016,532(7597):117-121. [28] MAYER I A,ARTEAGA C L.The PI3K/AKT pathway as a target for cancer treatment[J].Annual Review of Medicine,2016,67:11-28. [29] KARAR J,MAITY A.PI3K/AKT/mTOR pathway in angiogenesis[J].Frontiers in Molecular Neuroscience,2011,4:51. [30] 史东梅,董明,陆颖,等.PI3K/Akt信号通路与骨破坏:问题与机制[J].中国组织工程研究,2020,24(23):3716-3722. SHI D M,DONG M,LU Y,et al.PI3K/Akt signaling pathway and bone destruction:Problems and mechanisms[J].Chinese Journal of Tissue Engineering Research,2020,24(23):3716-3722.(in Chinese) [31] POLLARD T D,COOPER J A.Actin,a central player in cell shape and movement[J].Science,2009,326(5957):1208-1212. [32] TATYANA S.The actin cytoskeleton and actin-based motility[J].Cold Spring Harbor Perspectives in Bbiology,2018,10(1):a018267. [33] KIM D H,WIRTZ D.Focal adhesion size uniquely predicts cell migration[J].FASEB Journal,2013,27(4):1351-1361. [34] 冯志远,安晓莉,张宝平,等.细胞黏附斑生物力学研究的现状[J].中国组织工程研究与临床康复,2010,14(47):8843-8846. FENG Z Y,AN X L,ZHANG B P,et al.Research progress of focal adhesions in cell biomechanics[J].Chinese Journal of Tissue Engineering Research,2010,14(47):8843-8846.(in Chinese) [35] 刘红宾,田祥宇,王忠.肠道黏膜紧密连接与通透性研究进展[J].饲料研究,2015,2:18-23. LIU H B,TIAN X Y,WANG Z.Research progress of tight connection and permeability of intestinal mucosa[J].Feed Research,2015,2:18-23.(in Chinese) [36] CAMPBELL H K,MAIERS J L,DEMALI K A.Interplay between tight junctions & adherens junc-tions[J].Experimental Cell Research,2017,358(1):39-44. [37] 孙丽.lncRNA-FUT3as介导组蛋白H4修饰调控断奶仔猪F18大肠杆菌抗性的分子机制研究[D].扬州:扬州大学,2020. SUN L.Molecular mechanism of lncRNA-FUT3as mediated histone H4 modification to regulate Escherichia coli F18 resistance in weaned piglets[D].Yangzhou:Yangzhou University,2020.(in Chinese) [38] 钦伟云,甘丽娜,魏宗友,等.MUC4和MUC13基因在ETEC F18抗性型和易感型梅山断奶仔猪间的差异表达分析[J].中国畜牧兽医,2017,44(4):959-964. QIN W Y,GAN L N,WEI Z Y,et al.Differential expression analysis of MUC4 and MUC13 genes between resistant and sensitive weaned Meishan piglets to ETEC F18[J].China Animal Husbandry & Veterinary Medicine,2017,44(4):959-964.(in Chinese) [39] 黄礼燕,张声.MUC13的研究进展[J].临床与病理杂志,2014,34(3):312-316. HUANG L Y,ZHANG S.Research progress in MUC13[J].Journal of Clinical and Pathological Research,2014,34(3):312-316.(in Chinese) [40] ZHANG C,YANG X,QI Q,et al.lncRNA-HEIH in serum and exosomes as a potential biomarker in the HCV-related hepatocellular carcinoma[J].Cancer Biomark,2018,21(3):651-659. [41] CHEN M J,WANG X G,SUN Z X,et al.Diagnostic value of LncRNA-MEG3 as a serum biomarker in patients with hepatitis B complicated with liver fibrosis[J].European Review for Medical and Pharmacological Sciences,2019,23(10):4360-4367. [42] 朱晶.产肠毒素大肠杆菌、肠上皮细胞和乳酸菌相互关系的研究[D].上海:上海交通大学,2011. ZHU J.Studies on interactions between enteroto-xigenic Escherichia coli,intestinal epithelial cells and lactic acid bacteria[D].Shanghai:Shanghai Jiao Tong University,2011.(in Chinese) |