姜黄素对海南屯昌猪生长性能、饲料养分表观消化率和血清生化指标的影响

doi:10.16431/j.cnki.1671-7236.2023.05.014

Abstract

Abstract: 【Objective】 The aim of this experiment was to investigate the effects of different concentrations of curcumin supplementation on production performance,serum biochemical indexes and apparent feed digestibility of growing Hainan Tunchang pigs.【Method】 Eighty Hainan Tunchang pigs weighted 35.88 kg±0.25 kg were randomly divided into five groups,each group had 4 replicates,and 4 pigs for each replicate.The pigs in control group were fed with basal diet,and the pigs in antibiotic group were supplemented with 300 mg/kg mucocitractin sulfate in basal diet.The pigs in other 3 treatment groups were supplemented with 200 (Cur group 1),400 (Cur group 2) and 600 mg/kg(Cur group 3) curcumin in the basal diet, respectively.The pre-feeding period was 7 days,and the trial period was lasted 50 days.The experimental pigs were weighted on the 51 st day morning for the calculation of growth performance.Six pigs’serum in each group were randomly collected for the measurement of serum biochemical indicators.The fresh feces of 3 pigs were randomly collected for each repeat to determine the apparent digestibility of feed nutrients.【Result】 Compared with control group,average daily weight gain (ADG) was improved by 23.82% (P＜0.05),the ratio of feed and gain(F/G) was reduced by 20.06% (P＜0.05),the activity of serum AST and DAO content was reduced by 22.23% and 29.31%,respectively (P＜0.05),and serum IgA concentration was increased by 21.14% (P＜0.05) in Cur group 3. Compared with antibiotic group,the ADG of pigs was improved by 23.09% (P＜0.05),the apparent digestibility of crude fiber was increased by 42.14% (P＜0.05), and the activity of serum AST was reduced by 31.75% (P＜0.05) in Cur group 3.Compared with control and antibiotic groups,ADG of Cur groups 1 and 2 showed no significant difference(P＞0.05).Compared with control group,both of serum’D-lactic acid and DAO concentrations in Cur groups 1 and 2 were significantly reduced (P＜0.05),and the apparent digestibility of crude fiber of Cur group 2 was significantly increased than control and antibiotic groups(P＜0.05).【Conclusion】 Adding with 600 mg/kg curcumin could increase the growth performance and apparent digestibility of crude fiber in growing Hainan Tuncahng pigs,and improve the immune state of pigs,which could play an potential role for replacing antibiotics.

Key words: curcumin; Hainan Tunchang pig; growth performance; nutrient apparent digestibility; serum biochemical index

CLC Number:

S816.7

OUYANG Kun, WEI Limin, SUN Ruiping, XIE Yali, QI Qi, LI Xiang, LIU Quanwei, CHAO Zhe, ZHANG Yongliang, CHEN Ting. Effects of Curcumin on Growth Performance,Feed Apparent Digestibility and Serum Biochemical Indexes in Hainan Tunchang Pigs[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(5): 1867-1875.

References

[1] 许东晖,王胜,金晶,等.姜黄素的药理作用研究进展[J].中草药,2005,36(11):1737-1740. XU D H,WANG S,JIN J,et al.Advances in studies on pharmacological effect of curcumin[J].Chinese Traditional and Herbal Drugs,2005,36(11):1737-1740.(in Chinese)
[2] TOHAMY H G,EL OKLE O S,GOMA A A,et al.Hepatorenal protective effect of nano-curcumin against nano-ccopper oxide-mediated toxicity in rats:Behavioral performance,antioxidant,anti-inflammatory,apoptosis,and histopathology[J].Life Science,2022,292:120296.
[3] GAO Y,HU J H,LIANG X D,et al.Curcumin inhibits classical Swine fever virus replication by interfering with lipid metabolism[J].Veterinary Microbiology,2021,259:109152.
[4] 袁欢,曹敞,黄若澜,等.姜黄素防治畜禽代谢性疾病的研究进展[J].中国畜牧杂志,2022,58(5):71-76. YUN H,CAO C,HUANG R L,et al.Research progress on curcumin in the prevention and treatment of metabolic diseases in livestock and poultry[J].Chinese Journal of Animal Science,2022,58(5):71-76.(in Chinese)
[5] SHAHID H,SHAHZAD M,SHABBIR A,et al.Immunomodulatory and anti-inflammatory potential of curcumin for the treatment of allergic asthma:Effects on expression levels of pro-inflammatory cytokines and aquaporins[J].Inflammation,2019,42(6):2037-2047.
[6] GALLI G M,GRISS L G,BOIAGO M M,et al.Effects of curcumin and yucca extract addition in feed of broilers on microorganism control (anticoccidial and antibacterial),health,performance and meat quality[J].Research in Veterinary Science,2020,132:156-166.
[7] LOPRESTI A L.The Problem of curcumin and its bioavailability:Could its gastrointestinal influence contribute to its overall health-enhancing effects?[J].Advances In Nutrition,2018,9(1):41-50.
[8] 王斌,侯风琴.姜黄素对育肥猪生产性能,肉品质及胴体参数的影响[J].畜牧与兽医,2010,42(7):47-50. WANG B,HOU F Q.Effect of curcumin on production performance,meat quality and carcass parameters in fattening pigs[J].Animal Husbandry&Veterinary Medicine,2010,42(7):47-50.(in Chinese)
[9] 周明,张靖,申书婷,等.姜黄素在育肥猪中应用效果的研究[J].中国粮油学报,2014,29(3):67-73. ZHONG M,ZHANG J,SHEN S T,et al.The applide effects of curcumin in finishing swine[J].Journal of the Chinese Cereals and Oils Association,2014,29(3):67-73.(in Chinese)
[10] 芦娜,邱静芸,应志雄,等.日粮添加不同水平姜黄素对断奶仔猪生产性能,消化率和血液指标的影响[J].家畜生态学报,2017,38(1):30-35. LU N,QIU J Y,YING Z X,et al.Effects of varying levels of dietary curcumin on growth performance,digestibility and serum parameters of weaned piglets[J].Journal of Domestic Animal Ecology,2017,38(1):30-35.(in Chinese)
[11] CAO S,WANG C,YAN J,et al.Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway[J].Free Radical Biology and Medicine,2020,147:8-22.
[12] 猪饲养标准[M].北京:中国标准出版社,2004. Pig Feeding Standards[M].Beijing:Standards Press of China,2004.(in Chinese)
[13] XUN W,SHI L,ZHOU H,et al.Effects of curcumin on growth performance,jejunal mucosal membrane integrity,morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli[J].International Immunopharmacology,2015,27(1):46-52.
[14] NIU Y,HE J,ZHAO Y,et al.Effect of curcumin on growth performance,inflammation,insulin level,and lipid metabolism in weaned piglets with IUGR[J].Animals (Basel),2019,9(12):1098.
[15] 赵春萍,荀文娟,侯冠彧,等.姜黄素对大肠杆菌攻毒仔猪生长性能和抗氧化性能的影响[J].家畜生态学报,2015,36(7):24-27. ZHAO C P,XUN W J,HOU G H,et al.Effect of curcumin on growth performance and antioxidant performance in weared pigs counteracting Escherichia coli[J]. Journal of Domestic Animal Ecology,2015,36(7):24-27.(in Chinese)
[16] 邓卉,杨加豹,陈瑾,等.姜黄素对川藏黑仔猪生长性能、机体抗氧化及免疫功能的影响[J].中国饲料,2018,12:31-35. DENG H,YANG J B,CHEN J,et al.Effects of curcumin on growth performance,antioxidant and immunology function of Chuanzang Black piglets[J].China Feed,2018,12:31-35.(in Chinese)
[17] 杨泰,王慧,田科雄,等.姜黄素的生理功能及其在畜禽生产中的应用[J].动物营养学报,2017,29(10):3460-3466. YANG T,WANG H,TIAN K X,et al.Physiological function of curcumin and its application in livestock and poultry production[J].Chinese Journal of Animal Nutrition,2017,29(10):3460-3466.(in Chinese)
[18] ROJAS O J,STEIN H H.Processing of ingredients and diets and effects on nutritional value for pigs[J].Journal of Animal Science and Biotechnology,2017,8:48.
[19] VORLAPH I M.Influence of dietary curcumin on rumen fermentation,macronutrient digestion and nitrogen balance in beef cattle[J].American Journal of Agricultural&Biological Science,2011,6(1):7-11.
[20] 田光元,郝小燕,任国栋,等.饲粮中添加姜黄素对舍饲羔羊生长性能,营养物质表观消化率,能氮代谢和血清生化指标的影响[J].动物营养学报,2022,34(9):5964-5973. TIAN G Y,HAO X Y,REN G D,et al.Effects of dietary curcumin on growth performance,nutrients apparent digestibility,energy and nitrogen metabolism and serum biochemical indexes of barn feeding lambs[J]. Chinese Journal of Animal Nutrition,2022,34(9):5964-5973.(in Chinese)
[21] ZHAO Y,QIN G,SUN Z,et al.Effects of soybean agglutinin on intestinal barrier permeability and tight junction protein expression in weaned piglets[J].International Journal of Molecular Sciences,2011,12(12):8502-8512.
[22] WANG D,ZHOU L,ZHOU H,et al.Chemical composition and protective effect of guava (Psidium guajava L.) leaf extract on piglet intestines[J].Journal of the Science of Food and Agriculture,2021,101(7):2767-2778.
[23] LIU D Y,LOU W J,ZHANG D Y,et al.ROS plays a role in the neonatal rat intestinalbarrier damages induced by hyperoxia[J].Biomed Research International,2020,2020:8819195.
[24] 荀文娟,曹婷,施力光,等.姜黄素和丝裂原活化蛋白激酶信号通路抑制剂对断奶仔猪空肠黏膜形态,通透性以及紧密连接蛋白和炎性因子mRNA相对表达量的影响[J].动物营养学报,2019,31(3):1415-1421. XUN W J,CAO T,SHI L G,et al.Effects of curcumin and inhibitors of mitogen activated protein kinase pathways on jejunal mucosal morphology,permeability and mRNA relative expression levels of tight junction proteins and inflammatory cytokines in weaned piglets[J].Chinese Journal of Animal Nutrition,2019,31(3):1415-1421.(in Chinese)
[25] ALI O,SZABÓ-FODOR J,FÉBEL H,et al.Porcine hepatic response to fumonisin B (1) in a short exposure period:Fatty acid profile and clinical investigations[J].Toxins,2019,11(11):655.
[26] SHEN G,XU C,HU R,et al.Modulation of nuclear factor E2-related factor 2-mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin[J].Molecular Cancer Therapeutics,2006,5(1):39-51.
[27] 韦文耀.日粮添加姜黄素和白藜芦醇对断奶仔猪肝脏抗氧化和脂代谢的影响[D].南京:南京农业大学,2019. WEI W Y.Effects of dietary addition of curcumin and resveratrol on antioxidant and lipid meta bolism in liver of weaned piglets[D]. Nanjing:Nanjing Agricultural University,2019.(in Chinese)
[28] XU G,GU Y,YAN N,et al.Curcumin functions as an anti-inflammatory and antioxidant agent on arsenic-induced hepatic and kidney injury by inhibiting MAPKs/NF-κB and activating Nrf2 pathways[J].Environmental Toxicology,2021,36(11):2161-2173.
[29] LU K,LEE M H,PATEL S B.Dietary cholesterol absorption:More than just bile[J].Trends in Endocrinology and Metabolism,2001,12(7):314-320.
[30] 王琳,马黎,张博,等.大型迪庆藏猪不同生长阶段背脂与腹脂脂质代谢差异基因及调控网络分析[J].畜牧兽医学报,2023,54(2):520-533. WANG L,MA L,ZHANG B,et al.Key genes and regulatory network analysis of lipid metabolism differences between back fat and abdominal fat of large diqing tibeta pigs ant different growth stages[J].Chinese Journal of Animal and Veterinary Sciences,2023,54(2):520-533.(in Chinese)
[31] DIAO S,HUANG S,CHEN Z,et al.Genome-wide signatures of selection detection in three south China indigenous pigs[J].Genes (Basel),2019,10(5):346.
[32] GENG A L,ZHANG Y,ZHANG J,et al.Effects of light regime on the hatching performance,body development and serum biochemical indexes in Beijing You chicken[J].Journal of Poultry Science,2021,100(8):101270.
[33] MEGHA K B,MOHANAN P V.Role of immunoglobulin and antibodies in disease management[J].International Journal of Biological Macromoleculesv,2021,169:28-38.
[34] 唐佳希,喻国均,崔清明,等.桑叶提取物对生长猪生长性能,养分表观消化率及血清生化指标的影响[J].动物营养学报,2022,34(5):2862-2871. TANG J X,YU G J,CUI Q M,et al.Effects of mulberry leaf extract on growth performance,nutrient apparent digestibility and serum biochemical indexes of growing pigs[J].Chinese Journal of Animal Nutrition,2022,34(5):2862-2871.(in Chinese).
[35] 荀文娟,周汉林,侯冠彧,等.姜黄素对早期断奶仔猪回肠黏膜形态、紧密连接蛋白和炎性因子基因表达以及血清免疫球蛋白水平的影响[J].动物营养学报,2016,28(3):826-833. XUN W J,ZHOU H L,HOU G Y,et al.Effects of curcumin on lleum mucosal morphology,gene expression of tight junction proteins and inflammatory cytokines,and serum lmmunoglobulin levels of early weaning piglets[J].Chinese Journal of Animal Nutrition,2016,28(3):826-833.(in Chinese)
[36] LIU M,LU Y,GAO P,et al.Effect of curcumin on laying performance,egg quality,endocrine hormones,and immune activity in heat-stressed hens[J].Journal of Poultry Science,2020,99(4):2196-2202.

Effects of Curcumin on Growth Performance,Feed Apparent Digestibility and Serum Biochemical Indexes in Hainan Tunchang Pigs

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