维生素D受体基因与骨代谢关系的研究

›› 2008, Vol. 1 ›› Issue (11): 44-48.

• 生理生化 • Previous Articles Next Articles

The VDR Gene Polymorphsims and Bone Metabolism

GU Fengying1,WEN Shengping2,CAO Zhenhui2,GU Dahai1,WANG Zhicun1,WANG Jinhao1,GE Changrong2,JIA Junjing2

1. Faculty of Food Science, Yunnan Agricultural University, Kunming 650201,China；2. Yunnan Provincial Laboratory of Animal Nutrition and Feed Science,Yunnan Agricultural University, Kunming 650201,China

Received:1900-01-01 Revised:1900-01-01 Online:2008-11-20 Published:2008-11-20

Abstract

Abstract: In recently, a number of researchers have focused on the relationship between vitamin D receptor (VDR) and bone metabolism. It has been shown that the vitamin D that the active metabolite is 1,25(OH)₂ vitamin D₃, has play in important role in the regulation bone metabolism and absorption of calcium and phosphorous. The VDR is easily expressed polymorphisms in the different communities even the different individuals. It have been reported that the four single nucleotide polymorphisms of VDR were FokI，BsmI，ApaI，TaqI. The purpose of this review is to summarize the progress of the relationship between VDR gene polymorphsims and bone metabolism in aspects of calcium absorption, bone mass, bone mineral density, osteoporosis and rickets and so on.

Key words: VDR gene; polymorphisms; bone metabolism

CLC Number:

Q343.1⁺5

GU Fengying;WEN Shengping;CAO Zhenhui;GU Dahai;WANG Zhicun;WANG Jinhao;GE Changrong;JIA Junjing. The VDR Gene Polymorphsims and Bone Metabolism[J]. , 2008, 1(11): 44-48.

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The VDR Gene Polymorphsims and Bone Metabolism

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