China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (5): 1994-2000.doi: 10.16431/j.cnki.1671-7236.2022.05.041

• Preventive Veterinary Medicine • Previous Articles     Next Articles

Research Progress on Bovine Hepacivirus

GUO Luanying1, LI Jialei2, JIN Qinqin1, MA Jun1, LIU Quan1   

  1. 1. School of Life Science and Engineering, Foshan University, Foshan 528000, China;
    2. Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  • Received:2021-11-18 Online:2022-05-05 Published:2022-04-29

Abstract: Bovine hepacivirus,the novel member of the Hepacivirus,which was firstly discovered at bovine serum in Germany in 2015,has been found in 7 countries through high-throughput sequencing and has been divided into 2 genotypes and 8 subtypes,with at least 4 subtypes reported in China.Bovine hepacivirus whose hosts are member of Bovidae family,characterized by liver tropism,can cause acute or persistent infections in cattle,posing a potential threat to the development of the livestock industry and the health of related personnel.Bovine hepacivirus includes a genome of 8.8 kb,comprising 5'-UTR,3'-UTR and a long open reading frame (ORF) encoding 2 779 amino acids,and there is an internal ribosome entry site (IRES) associated with viral translation in 5'-UTR.Bovine hepacivirus,for which the main detection methods contain molecular biological diagnosis (nested-PCR) and immunological diagnosis (luciferase immunoprecipitation systems,LIPS),showing highly prevalent in cattle.However,with the increasingly development of emerging viruses,nested PCR may not detect Bovine hepacivirus with high genetic variation,and immunological tests may have cross-reactivity.So far,there is not only a lack of effective vaccines and other therapeutic drugs,but also a lack of awareness and measures of prevention and control towards Bovine hepacivirus in livestock farms.Therefore,this article of the latest research advances in the etiology,epidemiology,detection methods,prevention and control of bovine hepacivirus aims to increase awareness of Bovine hepacivirus,which can provide some reference and guidance for the research,prevention and control of the virus.

Key words: Bovine hepacivirus; high-throughput sequencing; epidemiology; detection methods; genetic diversity

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