lncRNA作为竞争性内源分子的作用机制及研究进展

doi:10.16431/j.cnki.1671-7236.2021.10.011

Abstract

Abstract: The competitive endogenous RNA (ceRNA) hypothesis suggests that transcripts with the same microRNA (miRNA) response element (MRE) bind to the miRNA in a competitive manner, thereby affecting the expression levels of transcripts. The ceRNA hypothesis subverts the traditional concept of one-way regulation between miRNA and target genes, and has great biological significance in RNA regulatory networks. Among many transcripts, long non-coding RNA (lncRNA) is a class of non-coding RNA with a sequence length of more than 200 nucleotides. The study of lncRNA involves in genetics, molecular biology, gene regulation, diseases (cancer, neurological diseases, etc. ) and other fields. miRNA and lncRNA form an interactive regulatory network, and lncRNA can be used as ceRNA to inhibit the function of miRNA, thereby affecting the expression of subsequent genes. In recent years, with the development of bioinformatics technology, researchers have found that the mechanism of ceRNA is not only related to human cancer diseases, but also plays an important regulatory role in the biological processes of muscle cell differentiation, adipocyte differentiation and granulosa cell apoptosis in various complex animals. The author reviewed the regulation mechanism of ceRNA, analyzed the influencing factors of ceRNA network regulation, and reviewed the research progress of lncRNA as ceRNA regulating miRNA in different animals, so as to provide reference for further research on the regulation network of lncRNA and miRNA, and provide new ideas for the development of animal husbandry and complex animal disease treatment.

Key words: long non-coding RNA; competing endogenous RNA; microRNA; microRNA response element

CLC Number:

Q527

LIU Mengxin, DU Shuangyang, YANG Jingcang, HUANG Xianya, GUO Yubing, LI Yingshuo, GUO Kaijun, CAO Suying. Mechanism and Research Progress of lncRNA as Competitive Endogenous Molecules[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(10): 3604-3613.

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Mechanism and Research Progress of lncRNA as Competitive Endogenous Molecules

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