LncRNA在动物科学中的研究进展

doi:10.16431/j.cnki.1671-7236.2015.06.015

Abstract

Abstract: Long noncoding RNA (LncRNA) constituted a novel class of non-protein coding transcripts longer than 200 nt,and were localized in nuclear and cytoplasmic.LncRNA can regulate gene expression in cis and trans,were recognized as a kind of key regulatory molecules.LncRNA were involved in various aspects of cell biology and disease,such as cell differentiation,X chromosome inactivation,cancer,immune,neurological and cardiovascular system disorders.In this paper,we mainly summarized the origions,research status and action mechanism of LncRNA,as well as overseas and domestic research status of LncRNA in animal husbandry and veterinary.Finally,the potential research and application prospects of LncRNA in animal science were put forward.

Key words: long non-coding RNA; gene expression regulation; development; immune

CLC Number:

Q522

ZHAO Jian-kang, ZANG Chang-jiang, JIANG Bao-chun. Research Progress on LncRNA in Animal Science[J]. , 2015, 42(6): 1424-1428.

References

[1] Nagano T,Fraser P.No-nonsense functions for long noncoding RNAs[J]. Cell,2011,145(2):178-181.

[2] Ponting C P,Oliver P L,Reik W.Evolution and functions of long noncoding RNAs[J].Cell,2009,136(4):629-641.

[3] Guttman M,Rinn J L.Modular regulatory principles of large non-coding RNAs[J]. Nature,2012,482(7385):339-346.

[4] Pauli A,Rinn J L,Schier A F.Non-coding RNAs as regulators of embryogenesis[J].Nat Rev Genet,2011,12(2):136-149.

[5] Knowling S,Morris K V.Non-coding RNA and antisense RNA.Nature's trash or treasure[J].Biochimie,2011,93(11):1922-1927.

[6] Lee J T.Epigenetic regulation by long noncoding RNAs[J].Science,2012,338(6113):1435-1439.

[7] Tsai M C,Manor O,Wan Y,et al.Long noncoding RNA as modular scaffold of histone modification complexes[J].Science,2010,329(5992):689-693.

[8] Wang K C,Yang Y W,Liu B,et al.A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression[J]. Nature,2011,472(7341):120-124.

[9] Di Ruscio A,Ebralidze A K,Benoukraf T,et al.DNMT1-interacting RNAs block gene-specific DNA methylation[J]. Nature,2013,503(7476):371-376.

[10] Kino T,Hurt D E,Ichijo T,et al.Noncoding RNA Gas5 is a growth arrest-and starvation-associated repressor of the glucocorticoid receptor[J].Sci Signal,2010,3(107):ra8.

[11] Espinoza C A,Allen T A,Hieb A R,et al.B2 RNA binds directly to RNA polymerase Ⅱ to repress transcript synthesis[J]. Nature Structural & Molecular Biology,2004,11(9):822-829.

[12] Mariner P D,Walters R D,Espinoza C A,et al.Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock[J]. Mol Cell,2008,29(4):499-509.

[13] Peterlin B M,Price D H.Controlling the elongation phase of transcription with P-TEFb[J]. Mol Cell,2006,23(3):297-305.

[14] Nguyen V T,Kiss T,Michels A A,et al.7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes[J].Nature,2001,414(6861):322-325.

[15] Zhao X,Tang Z,Zhang H,et al.A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons[J].Nature Neuroscience,2013,16(8):1024-1031.

[16] Cesana M,Cacchiarelli D,Legnini I,et al.A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA [J]. Cell,2011,147(2):358-369.

[17] Wang J Y,Liu X F,Wu H C,et al.CREB up-regulates long non-coding RNA,HULC expression through interaction with microRNA-372 in liver cancer[J].Nucleic Acids Res,2010,38(16):5366-5383.

[18] Poliseno L,Salmena L,Zhang J,et al.A coding-independent function of gene and pseudogene mRNAs regulates tumour biology[J]. Nature,2010,465(7301):1033-1038.

[19] Franco-Zorrilla J M,Valli A,Todesco M,et al.Target mimicry provides a new mechanism for regulation of microRNA activity[J].Nat Genet,2007,39(8):1033-1037.

[20] Batista P J,Chang H Y.Long noncoding RNAs:Cellular address codes in development and disease[J].Cell,2013,152(6):1298-1307.

[21] Ulitsky I,Shkumatava A,Jan C H,et al.Conserved function of LincRNAs in vertebrate embryonic development despite rapid sequence evolution [J].Cell,2011,147(7):1537-1550.

[22] Yang L Q,Lin C R,Rosenfeld M G.A LincRNA switch for embryonic stem cell fate[J]. Cell Res,2011,21(12):1646-1648.

[23] Tinzl M,Marberger M,Horvath S,et al.DD3PCA3 RNA analysis in urine——A new perspective for detecting prostate cancer[J]. European Urology,2004,46(2):182-186.

[24] Huarte M,Guttman M,Feldser D,et al.A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response[J]. Cell,2010,142(3):409-419.

[25] Kogo R,Shimamura T,Mimori K,et al.Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers [J].Cancer Res,2011,71(20):6320-6326.

[26] Wang P,Xue Y,Han Y,et al.The STAT3-binding long noncoding RNA Lnc-DC controls human dendritic cell differentiation[J]. Science,2014,344(6181):310-313.

[27] Carpenter S,Aiello D,Atianand M K,et al.A long noncoding RNA mediates both activation and repression of immune response genes[J]. Science,2013,341(6147):789-792.

[28] Zhou Z Y,Li A M,Adeola A C,et al.Genome-wide identification of long intergenic noncoding RNA genes and their potential association with domestication in pigs[J].Genome Biology and Evolution,2014,6(6):1387-1392.

[29] Arriaga-Canon C,Fonseca-Guzman Y,Valdes-Quezada C,et al.A long non-coding RNA promotes full activation of adult gene expression in the chicken alpha-globin domain[J]. Epigenetics:Official Journal of the DNA Methylation Society,2014,9(1):173-181.

[30] Roeszler K N,Itman C,Sinclair A H,et al.The long non-coding RNA,MHM,plays a role in chicken embryonic development,including gonadogenesis[J]. Developmental Biology,2012,366(2):317-326.

[31] Boulanger L,Pannetier M,Gall L,et al.FOXL2 is a female sex-determining gene in the goat[J].Curr Biol,2014,24(4):404-408.

[32] Huang W,Long N,Khatib H.Genome-wide identification and initial characterization of bovine long non-coding RNAs from EST data[J].Animal Genetics,2012,43(6):674-682.

[33] Zhou Y,Sun J,Li C,et al.Characterization of transcriptional complexity during adipose tissue development in bovines of different ages and sexes[J]. PLoS One,2014,9(7):e101261.

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