Mpeg1在病原清除中的作用及分子机制

doi:10.16431/j.cnki.1671-7236.2023.04.030

Abstract

Abstract: Macrophage-expressed gene 1 (Mpeg1) protein is a pore-forming protein belonging to the membrane attack complex/perforin (MACPF) superfamily.It is widely found in animals and is considered to be the oldest MACPF pore-forming protein in existence.Mpeg1 is involved in host innate immunity by killing bacteria,viruses and parasites.In antimicrobial immunity,cells with high expression of Mpeg1 can resist variety of pathogens such as intracellular bacteria,extracellular bacteria,acid-resistant bacteria and drug-resistant bacteria.In the host,the spread and infection of pathogens is limited and the development of chronic progressive diseases is inhibited indirectly by this broad-spectrum bactericidal activity.In anti-parasitic immunity,Mpeg1 can directly kill Cryptocaryon irritans,Miamiensis avidus and other protozoa.In antiviral immunity,cytokines induce the expression of Mpeg1 to resist viral infection.The studies in recent years have shown that Mpeg1 plays an important role in inflammatory response,antigen presentation and initial diagnosis of some tumor diseases.The molecular mechanism of Mpeg1 in pathogen clearance:The induced expression of Mpeg1 is redistributed in cells through ubiquitination and finally co-localized with pathogens in lysosomes,the acidic environment triggers Mpeg1 to form pores on the surface of bacteria,various antimicrobial effectors enter pathogens to participate in pathogen clearance.The discovery,pathogen clearance and other immune-related functions,and its molecular mechanisms were reviewed in this article,in order to provide reference for the further research and application of Mpeg1.

Key words: macrophage-expressed gene 1 (Mpeg1); immune response; pathogen clearance; antibacterial mechanism; inflammation

CLC Number:

GUO Bingyu, LI Li, LI Chen, KONG Xianghui. Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1584-1592.

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Role and Molecular Mechanism of Mpeg1 in Pathogen Clearance

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