病原感染后鸡miRNAs调控的研究进展

doi:10.16431/j.cnki.1671-7236.2022.05.031

Abstract

Abstract: microRNAs (miRNAs) are a class small non-coding RNAs with short single chain.Both during normal development and the occurrence and development of disease,miRNA can bind to the target mRNA,participate in post-transcriptional regulation of genes and play an important role.Recently,with the in-depth study of miRNAs,more and more evidence showed that pathogen infection will change the expression level of host miRNAs.These differentially expressed miRNAs can actively participate in the occurrence and development of the disease,and participate in immune function,autophagy,inflammation,metabolism and other biological processes to inhibit or promote the development of the disease by inhibiting target genes expression.In addition,host miRNAs as a small RNA involved in post-transcriptional regulation,during the pathogens infection process,chicken miRNAs not only target their own genes to regulate chicken innate immune signals but also target pathogenic genes to affect pathogen adsorption,invasion,proliferation,and so on.This paper mainly introduces the biosynthesis and function of miRNAs and the regulatory role and mechanism of chicken miRNAs in the invasion and pathogenesis of some viruses,bacteria and parasites,and briefly describes the regulation strategies of chicken miRNAs after different pathogens infection.This paper reviews the biogenesis and function of miRNAs and miRNA regulatory mechanism during pathogen invasion and pathogenic process,briefly describes the regulation strategy of chicken miRNAs after infection with different pathogens,to provide some references for the diagnosis,treatment,prevention and control of chicken disease from the point of view of chicken miRNAs.

Key words: miRNA; viruses; bacteria; immune response; chicken

CLC Number:

S855

ZHANG Yuming, CHEN Qiaoguang, HOU Zhaofeng, LIU Dandan, TAO Jianping, XU Jinjun. Research Progress on Chicken miRNAs and Their Regulation Role After Pathogenic Infection[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(5): 1908-1916.

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Research Progress on Chicken miRNAs and Their Regulation Role After Pathogenic Infection

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