China Animal Husbandry and Veterinary Medicine ›› 2023, Vol. 50 ›› Issue (3): 1007-1015.doi: 10.16431/j.cnki.1671-7236.2023.03.016

• Nutrition and Feed • Previous Articles     Next Articles

Protective Effect of Honokiol on Cadmium-induced Renal Injury in Chickens

HUANG Xiaoqian1,3, YUAN Junzhao1, LIU Jinhe2, ZOU Hui1, GU Jianhong1, YUAN Yan1, LIU Xuezhong1, LIU Zongping1,3, BIAN Jianchun1,3   

  1. 1. College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China;
    2. Kumar Biotechnology Corporation Biotron Ltd., Yangzhou 225124, China;
    3. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, China
  • Received:2022-09-02 Online:2023-03-05 Published:2023-03-02

Abstract: 【Objective】 This study was aimed to study the protective effect of honokiol (HNK) on renal injury in animals exposed to cadmium (Cd).【Method】 Forty eight Sanhuang chickens with similar body weight (61.05 g±2.00 g) and good health conditions were randomly divided into four groups,each group had three replicates and each replicate had four chickens.The chickens in control group was fed with basal diet,in Cd group, 70 mg/kg cadmium chloride were added in the basal diet,in HNK group, 400 mg/kg HNK were added in the basal diet, and in the combined treatment group (HNK+Cd group), 70 mg/kg cadmium chloride and 400 mg/kg HNK were added in the basal diet.The feeding period was 30 days.【Result】 Compared with control group,the content of cadmium in the kidney,the serum uric acid (UA) and creatinine (CREA) contents were extremely significantly increased (P<0.01),the lumen of the renal crypt was enlarged and the number of apoptotic cells was increased,the contents of selenium,iron,and manganese in kidney were extremely significantly decreased (P<0.01),and the contents of zinc and copper in kidney were extremely significantly increased(P<0.01) in Cd group.The contents of zinc and iron in kidney were extremely significant or significantly increased (P<0.01 or P<0.05),and there were no significant differences in the cadmium,selenium,copper,and manganese contents of kidney,and serum UA and CREA contents in HNK group (P>0.05).Compared with Cd group,for the chickens in HNK+Cd group,the contents of cadmium,copper in kidney and serum UA were significantly decreased (P<0.05),the content of CREA was decreased,but the difference was not significant (P>0.05),the contents of selenium,zinc,iron,and manganese in kidney were significantly increased (P<0.05),and the renal tubular cell injury was alleviated and the number of apoptotic cells was also reduced.【Conclusion】 HNK could reduce the accumulation of cadmium in kidney,reduce the number of apoptotic cells in kidney tissue,alleviate renal injury,improve the metabolism disorder of trace elements in chicken,and enhance the constitution of chicken.

Key words: honokiol(HNK); cadmium; chicken; renal injury; apoptosis; trace element

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