植物多糖对动物肠道的保护作用及其分子机制

doi:10.16431/j.cnki.1671-7236.2022.01.016

Abstract

Abstract: The intestinal tract is the main part of digestion and absorption of nutrients, but it is easy to be stimulated by the external environment to cause pathological changes. The frequent occurrence of animal intestinal diseases seriously affects the growth and development process of animals, increases the feeding cost of animals, and has a huge impact on the economic benefits of breeding industry. Although antibiotics are an effective strategy to alleviate the occurrence and development of intestinal diseases, people have to develop new environment-friendly treatments because of their drug resistance and drug residues. Plant polysaccharides widely exist in plants in nature, and have the characteristics of high efficiency, non-toxic side effects and no residue. As a green feed additive, plant polysaccharides can prevent intestinal diseases and improve animal production performance. It is mainly through the regulation of nuclear factor-κB(nuclear factor kappaB, NF-κB), mitogen activated protein kinase (MAPK), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and transforming growth factor-β (TGF-β), phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) and other signaling pathways to give full play to the physiological function of intestinal barrier, strengthen the interaction between various barriers, prevent animal intestinal diseases, regulate the level of intestinal inflammation, maintain the balance of intestinal microflora, enhance the body's antioxidant capacity and the immune function of animal body, and then, improve the quality of animal products to a certain extent, enhance the economic value created by animals. In this paper, the authors summarize the protective effects of plant polysaccharides on animal intestine and its molecular mechanism and expound its application and effect in animal production, in order to provide reference for the application of plant polysaccharides in animal production.

Key words: plant polysaccharides; intestinal inflammation; intestinal barrier; molecular mechanism

CLC Number:

S816.7

MAO Xinyu, LIANG Hui, WANG Hang, DONG Na. Protective Effects of Plant Polysaccharides on Animal Intestine and Its Molecular Mechanism[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 150-160.

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Protective Effects of Plant Polysaccharides on Animal Intestine and Its Molecular Mechanism

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