酪氨酸磷酸化在精子获能过程中的作用

doi:10.16431/j.cnki.1671-7236.2018.09.018

Abstract

Abstract:

Capacitation is an important physiological prerequisite before sperm cells undergo acrosome reaction and fertilize oocytes.Capacitation is a more sophisticated phenomenon that occurs in the female reproductive tract,it gives sperm the ability to enhance activity,interact with zona pellucida (ZP),perform acrosome reaction and initiate the fusion with the oocyte plasma membrane,and complete the fertilization process.However,the molecular mechanism of sperm capacitation is very complex,although it is not yet fully defined,but the sperm has many structural and biochemical changes after capacitation,such as protein tyrosine phosphorylation,the cholesterol exodus of the sperm membrane,the production of active oxygen and the hyperpolarization of the sperm membrane.Proteins regulate some important phenomena such as capacitation and acrosome reaction by phosphorylation or dephosphorylation,this is the process that sperm must undergo to reach,bind,penetrate and fuse the oocyte.Therefore,protein phosphorylation is a very important process of capacitation,especially phosphorylation at tyrosine residues,which is one of the most important events in the process of capacitation,and tyrosine phosphorylation may be the main or even the only indicator of signal transduction pathways in cells.This text focuses on protein phosphorylation,the discovery,role and localization of tyrosine phosphorylation in sperm,and several factors affecting tyrosine phosphorylation in the process of capacitation.

Key words: sperm capacitation; molecular mechanism; tyrosine phosphorylation

CLC Number:

S814.4

CHEN Xuan, JIN Yi. The Role of Tyrosine Phosphorylation in Sperm Capacitation[J]. , 2018, 45(9): 2486-2491.

References

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The Role of Tyrosine Phosphorylation in Sperm Capacitation

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