无尾鸡骨骼发育关键信号通路研究进展

doi:10.16431/j.cnki.1671-7236.2021.06.014

Abstract

Abstract: The skeletal system is crucial to the life activities of the organism,it provides the hematopoietic micro-environment,mechanical support,organ protection and other functions,as well as a reservoir of calcium and other minerals.The phenotypic diversity of chicken tailbone is a good resource for study of skeletal phylogeny and mechanism.To understand the molecular mechanism of skeletal developmental termination in the Rumpless chicken,this paper summarized the development of skeletal,the skeletal research in Rumpless chicken,and focus on the key signaling pathways of Notch and Wnt that influence the characteristics of rumpless and research progress of the Rumpless chicken.Target genes of Notch and Wnt signaling pathways and their interactions can form the characteristic of periodic expression,which is a molecular pathway regulating body segment formation and tailbone extension.However,the precise regulation of the interaction between the receptor and ligand and the core elements in the signaling pathway are still unclear,and more functional genomic and proteomic technology are needed for further study.

Key words: Rumpless chicken; bone development; molecular mechanism; Notch signaling pathway; Wnt signaling pathway

CLC Number:

S831

QI Wangmei, XU Siriguleng, HA Dengchuriya, LIU Bin, HU Sile, SUN Yanyong, ZHANG Wenguang. Research Progress on Key Signaling Pathways in Bone Development of Rumpless Chicken[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(6): 2011-2019.

References

[1] NOORAI R E,SHANKAR V,FREESE N H,et al.Discovery of genomic variations by whole-genome resequencing of the North American Araucaa chicken[J].PLoS One,2019,14(12):e0225834.
[2] 胡斯乐.有尾鸡与无尾鸡比较基因组学研究[D].呼和浩特:内蒙古农业大学,2018. HU S L.Comparative genomic analysis of tailed chicken and rumples chicken[D].Hohhot:Inner Mongolia Agricultural University,2018.(in Chinese)
[3] JAKOVLJEVIC A,MILETIC M,NIKOLIC N,et al.Notch signaling pathway mediates alveolar bone resorption in apical periodontitis[J].Medical Hypotheses,2019,124:87-90.
[4] GONG H,WANG H,WANG Y,et al.Skin transcriptome reveals the dynamic changes in the Wnt pathway during integument morphogenesis of chick embryos[J].PLoS One,2018,13(1):e0190933.
[5] LEE K,SKROMNE I.Retinoic acid regulates size,pattern and alignment of tissues at the head-trunk transition[J].Development,2014,141(22):4375-4384.
[6] 胡斯乐,陶萨如拉,王月星,等.鸡无尾性状的分子机制研究进展[J].中国畜牧兽医,2018,45(1):154-161. HU S L,TAO S R L,WANG Y X,et al.Research progress on molecular mechanisms of rumples trait in chicken[J].China Animal Husbandry & Veterinary Medicine,2018,45(1):154-161.(in Chinese)
[7] SOLTANOFF C S,YANG S,CHEN W,et al.Signaling networks that control the lineage commitment and differentiation of bone cells[J].Critical Reviews in Eukaryotic Gene Expression,2009,19(1):1-46.
[8] WU M,DENG L,ZHU G.G protein and its signaling pathway in bone development and disease[J].Frontiers in Bioscience,2010,15:957-985.
[9] 宋迟,韩威,胡艳,等.无尾瓢鸡尾部骨骼缺失观察[J].中国家禽,2014,36(18):53-56. SONG C,HAN W,HU Y,et al.Observation of bone loss in the tail of Rumpless Piao chicken[J].China Poultry,2014,36(18):53-56.(in Chinese)
[10] BUCKINGHAM K J,MCMILLIN M J,BRASSIL M M,et al.Multiple mutant T alleles cause haploinsu-fficiency of brachyury and short tails in Manx cats[J].Mammalian Genome,2013,24(9-10):400-408.
[11] WU B,SHAO Y,CHEN B,et al.Identification of a novel mouse brachyury (T) allele causing a short tail mutation in mice[J].Cell Biochemistry and Biophysics,2010,58(3):129-135.
[12] ZHI D,DA L,LIU M,et al.Whole genome sequencing of Hulunbuir Short-tailed sheep for identifying candidate genes related to the short-tail phenotype[J].G3 (Bethesda,Md.),2018,8(2):377-383.
[13] WU B,SHAO Y,CHEN B,et al.Identification of a novel mouse brachyury (T) allele causing a short tail mutation in mice[J].Cell Biochemistry and Biophysics,2010,58(3):129-135.
[14] CHOI Y B,KIM G A,OH H J,et al.Cloning of the short-tailed Gyeongju Donggyeong dog via SCNT:Conserving phenotypic inheritance[J].The Journal of Veterinary Medical Science,2016,78(2):329-331.
[15] NOORAI R E,FREESE N H,WRIGHT L M,et al.Genome-wide association mapping and identification of candidate genes for the rumpless and ear-tufted traits of the Araucana chicken[J].PLoS One,2012,7(7):e40974.
[16] HAMBURGER V,HAMILTON H L.A series of normal stages in the development of the chick embryo[J].Developmental Dynamics,1992,195(4):231-272.
[17] LI D,CHE T,CHEN B,et al.Genomic data for 78 chickens from 14 populations[J].Gigascience,2017,6(6):1-5.
[18] ZANOTTI S,CANALIS E.Notch and the skeleton[J].Molecular and Cellular Biology,2010,30(4):886-896.
[19] MA H,WUY,ZHANG H.et al.Notch signaling in bone formation and related skeletal diseases[J].Zhonghua Yi Xue Yi Chuan Xue Za Zhi,2015,32(2):274-279.
[20] DEREGOWSKI V,GAZZERRO E,PRIEST L,et al.Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signaling[J].The Journal of Biological Chemistry,2006,281(10):6203-6210.
[21] SCIAUDONE M,GAZZERRO E,PRIEST L,et al.Notch 1 impairs osteoblastic cell differentiation[J].Endocrinology,2003,144(12):5631-5639.
[22] TEZUKA K,YASUDA M,WATANABE N,et al.Stimulation of osteoblastic cell differentiation by Notch[J].Journal of Bone and Mineral Research,2002,17(2):231-239.
[23] NOBTA M,TSUKAZAKI T,SHIBATA Y,et al.Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling[J].The Journal of Biological Chemistry,2005,280(16):15842-15848.
[24] MICHALIS L K,KATSOURAS C S,PAPAMI-CHAEL N,et al.Enoxaparin versus tinzaparin in non-ST-segment elevation acute coronary syndromes:The EVET trial[J].American Heart Journal,2003,146(2):304-310.
[25] ZANOTTI S,SMERDEL-RAMOVA A,CANALS E.Hes1 (hairy and enhancer of split 1) is a determinant of bone mass[J].The Journal of Biological Chemistry,2011,286(4):2648-2657.
[26] ZANOTTI S,CANALIS E.Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes[J].Endocrinology,2013,154(2):762-772.
[27] CANALIS E,PARKER K,FENG J Q,et al.Osteoblast lineage-specific effects of Notch activation in the skeleton[J].Endocrinology,2013;154(2):623-634.
[28] ENGIN F,YAO Z,YANG T,et al.Dimorphic effects of Notch signaling in bone homeostasis[J].Nature Medicine,2008,14(3):299-305.
[29] TAO J,CHEN S,YANG T,et al.Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent[J].Journal of Bone and Mineral Research,2010,25(10):2175-2183.
[30] EPPIG J T,BLAKE J A,BULT C J,et al.The mouse genome database (MGD):Comprehensive resource for genetics and genomics of the laboratory mouse[J].Nucleic Acids Research,2017,45(D1):D723-D729.
[31] QI J,LEE H J,SAQUET A,et al.Autoinhibition of dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways[J].The Journal of Biological Chemistry,2017,292(14):5898-5908.
[32] CORDLE J,REDFIELDZ C,STACEY M,et al.Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity[J].The Journal of Biological Chemistry,2008,283(17):11785-11793.
[33] MALECKI M J,SANCHEZ-IRIZARRY C,MITCHELL J L,et al.Leukemia-associated mutations within the Notch1 heterodimerization domain fall into at least two distinct mechanistic classes[J].Molecular and Cellular Biology,2006,26(12):4642-4651.
[34] BRUCKNER K,PEREZ L,CLAUSEN H,et al.Glycosyltransferase activity of fringe modulates Notch-delta interactions[J].Nature,2000,406(6794):411-415.
[35] STAUBER M,SACHIDANANDAN C,MORGENSTERM C,et al.Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis[J].PLoS One,2009;4(11):e7996.
[36] ACHARJEE U K,GEJIMA R,FELEMBA ATHARY ABDULHALEEM M,et al.Tsukushi expression is dependent on Notch signaling and oscillated in the presomitic mesoderm during chick somitogenesis[J].Biochemical and Biophysical Research Communica-tions,2015,465(3):625-630.
[37] LIU F,KOHLMEIER S,WANG C Y.Wnt signaling and skeletal development[J].Cell Signal,2008,20(6):999-1009.
[38] JENNY A.Planar cell polarity signaling in the Drosophila eye[J].Current Topics in Developmental Biology,2010,93:189-227.
[39] HARTMANN C,TABIN C J.Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton[J].Cell,2001,104(3):341-351.
[40] RAWADI G,ROMAN-ROMAN S.Wnt signalling pathway:A new target for the treatment of osteoporosis[J].Expert Opinion on Therapeutic Targets,2005,9(5):1063-1077.
[41] MOON R T,KOHN A D,DE FERRARI G V,et al.Wnt and beta-catenin signalling:Diseases and therapies[J].Nature Reviews. Genetics,2004,5(9):691-701.
[42] WANG Y,LI Y P,PAULSON C,et al.Wnt and the Wnt signaling pathway in bone development and disease[J].Frontiers in Bioscience,2014,19(3):379-407.
[43] LEE H H,BEHRINGER R R.Conditional expression of Wnt4 during chondrogenesis leads to dwarfism in mice[J].PLoS One,2007,2(5):e450.
[44] SPATER D,HILL T P,O'SULLIVAN R J,et al.Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis[J].Development,2006,133(15):3039-3049.
[45] HOUBEN A,KOSTANOVA-POLIAKOVA D,WEISSENBOCK M,et al.Beta-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis[J].Deve-lopment,2016,143(20):3826-3838.
[46] AHRENS M J,ROMEREIM S,DUDLEY A T.A re-evaluation of two key reagents for in vivo studies of Wnt signaling[J].Developmental Dynamics,2011,240(9):2060-2068.
[47] SCHUMACHER C A,JOINER D M,LESS K,et al.Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6[J].Bone Research,2016,4:15042.
[48] GAUR T,RICH L,LENGNER C J,et al.Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation[J].Journal of Cellular Physiology,2006,208(1):87-96.
[49] NARCISI R,CLEARY M A,BRAMA P A,et al.Long-term expansion,enhanced chondrogenic potential,and suppression of endochondral ossification of adult human MSCs via Wnt signaling modulation[J].Stem Cell Reports,2015,4(3):459-472.
[50] WANG B,JIN H,ZHU M,et al.Chondrocyte β-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model[J].Arthritis & Rheumatology,2014,66(1):107-120.
[51] CANDELA M,CANTLEY L,YASUAHA R,et al.Distribution of slow-cycling cells in epiphyseal cartilage and requirement of beta-catenin signaling for their maintenance in growth plate[J].Journal of Orthopaedic Research,2014,32(5):661-668.
[52] YUASA T,KONDO N,YASUHARA R,et al.Transient activation of Wnt/beta-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice[J].The American Journal of Pathology,2009,175(5):1993-2003.
[53] MARUYAMA T,JIANG M,HSU W.Gpr177,a novel locus for bone mineral density and osteoporosis,regulates osteogenesis and chondrogenesis in skeletal development[J].Journal of Bone and Mineral Research,2013,28(5):1150-1159.
[54] GOLOVCHENKO S,HATTORI T,HARTMANN C,et al.Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation[J].Bone,2013,55(1):102-112.
[55] VEEMAN M T,AXELROD J D,MOON R T.A second canon.Functions and mechanisms of beta-catenin-independent Wnt signaling[J].Developmental Cell,2003,5(3):367-377.
[56] MOVERARE-SKRTIC S,HENNING P,LIU X,et al.Osteoblast-derived Wnt16 represses osteoclastogenesis and prevents cortical bone fragility fractures[J].Nature Medicine,2014,20(11):1279-1288.
[57] MOVERARE-SKRTIC S,WU J,HENNING P,et al.The bone-sparing effects of estrogen and Wnt16 are independent of each other[J].Proceedings of the National Academy of Sciences of the United States of America,2015,112(48):14972-14977.
[58] KOBAYASHI Y,THIRUKONDA G J,NAKAMURA Y,et al.Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a[J].Biochemical and Biophysical Research Communications,2015,463(4):1278-1283.
[59] ALAM I,ALKHOULI M,GERARD-O'RILEY R L,et al.Osteoblast-specific overexpression of human Wnt16 increases both cortical and trabecular bone mass and structure in mice[J].Endocrinology,2016,157(2):722-736.
[60] MIYAMOTO K,OHKAWARA B,ITO M,et al.Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling[J].PLoS One,2017,12(9):e0184388.
[61] NALESSO G,THOMAS B L,SHERWOOD J C,et al.Wnt16 antagonises excessive canonical Wnt activation and protects cartilage in osteoarthritis[J].Annals of the Rheumatic Diseases,2017,76(1):218-226.
[62] JOENG K S,SCHUMACHER C A,ZYLSTRA-DIEGEL C R,et al.Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo[J].Developmental Biology,2011,359(2):222-229.
[63] KRAMER I,HALLEUX C,KELLER H,et al.Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis[J].Molecular and Cellular Biology,2010,30(12):3071-3085.
[64] LARA-CASTILLO N,KIM-WEROHA N A,KAMEL M A,et al.In vivo mechanical loading rapidly activates beta-catenin signaling in osteocytes through a prostaglandin mediated mechanism[J].Bone,2015,76:58-66.
[65] AULEHLA A,WEHRLE C,BRAND-SABERI B,et al.Wnt3a plays a major role in the segmentation clock controlling somitogenesis[J].Developmental Cell,2003,4(3):395-406.
[66] KROL A J,ROELLIG D,DEQUEANT M L,et al.Evolutionary plasticity of segmentation clock networks[J].Development,2011,138(13):2783-2792.
[67] HARTMANN C,TABIN C J.Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton[J].Cell,2001,104(3):341-351.
[68] FREESE N H,LAM B A,STATON M,et al.A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken[J].PLoS One,2014,9(11):e112364.

Research Progress on Key Signaling Pathways in Bone Development of Rumpless Chicken

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