microRNA调控猪肌内脂肪沉积的研究进展

doi:10.16431/j.cnki.1671-7236.2022.11.022

Abstract

Abstract: Intramuscular fat (IMF) is a key indicator of pork quality, which can affect the tenderness, shear force, juiciness and flavor. microRNA (miRNA) is a class of short non-coding RNA with a length of about 22 nt, which plays an important role in various physiological processes such as embryonic development, adipogenic differentiation, muscle fiber formation, neuroregulation and immune response.More and more studies have shown that miRNA plays an important regulatory role in porcine IMF deposition and is an important regulator of lipid metabolism.By summarizing relevant studies at home and abroad on the regulation of porcine IMF deposition by miRNA, the authors found that miR-34a, miR-125a-5p, miR-32-5p could regulates porcine IMF deposition by targeting Krüppel-like factors (KLF) family members, miR-130a regulates porcine IMF deposition by targeting peroxisometer-activated receptor(PPAR) family members, miR-34a, miR-17-5p and miR-125A-5p can target other family members, such as acyl-CoA synthetase long chain family member 4(ACSL4) and Nuclear receptor coactivator 3 (NCOA3) regulate porcine IMF deposition.However, the specific mechanism of miRNA regulating porcine IMF is not fully understood and needs to be further explored.By sorting out the miRNAs that have been confirmed to be related to porcine IMF deposition, the authors sorted out the target genes and main pathways of related miRNAs, in order to provide convenience for screening IMF related miRNAs, provide new ideas and strategies for improving meat quality, and provide reference for elucidating the mechanism of miRNA in porcine lipid metabolism.

Key words: pigs; microRNA (miRNA); intramuscular fat (IMF); KLF family; PPAR family

CLC Number:

S814.8

HOU Junjie, SHI Zhuoyan, LIU Xiaoping, JI Xiang, CHU Xiaoran, SONG Zhen, WEN Fengyun. Research Progress on microRNA Regulation of Intramuscular Fat Deposition in Pigs[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(11): 4318-4326.

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Research Progress on microRNA Regulation of Intramuscular Fat Deposition in Pigs

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