lncRNA在猪流产相关病毒感染中的作用研究进展

doi:10.16431/j.cnki.1671-7236.2022.09.030

Abstract

Abstract: The reproductive capacity is an important factor to determine the production efficiency of pigs, and the abortion caused by virus infection seriously affects the reproductive efficiency of pigs.Understanding the pathogenic mechanism of porcine abortion-related viruses is helpful to improve the reproductive efficiency of pigs.However, a large number of studies have focused on the protein or genomic DNA of viruses and hosts.In recent years, long noncoding RNA (lncRNA) has revealed the interaction between viruses and hosts from a new perspective, it provides a new way to study the interaction between them.lncRNA is a transcription with a length of more than 200 nt, its function takes mainly through interaction with DNA, RNA, chromatin and protein, and is specifically expressed in certain developmental stages, tissues and disease states, and participates in various regulation of body.lncRNA is a key factor regulating the interaction between virus and host.After virus infects host, lncRNA is differentially expressed, and the corresponding target genes are enriched in inflammatory and immune-related signaling pathways, participating in inflammatory, immune and antiviral responses of body.In-depth understanding of the regulatory role of lncRNA between porcine abortion-related virus and host is of great significance for the prevention and treatment of porcine abortion caused by virus infection.In this paper, lncRNA and its relationship with porcine abortion-related viruses, host lncRNA and virus interaction and regulatory pathways were reviewed, and the existing problems and application prospects were introduced, in order to provide theoretical basis for porcine disease resistance breeding, development and design of porcine abortion-related drugs, and target treatment of abortion-related diseases.

Key words: long noncoding RNA (lncRNA); virus infection; pigs; abortion

CLC Number:

Q527⁺.5

YU Peng, NIU Xiaoyu, DONG Ling, LU Mengqi, CHEN Yanhong, LI Fan, SONG Hui. Research Progress on the Role of lncRNA in Porcine Abortion-related Virus Infection[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3559-3568.

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Research Progress on the Role of lncRNA in Porcine Abortion-related Virus Infection

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