基于选择信号分析揭示猪终端父本群体间性状趋同的关键基因

doi:10.16431/j.cnki.1671-7236.2022.08.014

Abstract

Abstract: 【Objective】 This study was aimed to reveal the genomic patterns of the phenotypic convergence of important economic traits in terminal sire Pietrain and Duroc pigs under artificial selection.【Method】 Based on the 50K SNP chips data of 376 Pietrain pigs,451 Duroc pigs line Ⅰ,841 Duroc pigs line Ⅱ and 497 Duroc pigs line Ⅲ,the integrated haplotype score (iHS) and allele frequency difference (△AF) were calculated in 100 kb windows with a step size of 50 kb,and the top 5% statistics of each method were taken as the putative selection signatures of ingroup and intergroup,respectively.The close selection signatures within the distance of 200 kb were merged by bedtools.The overlapping putative selection regions of iHS and △AF statistics between every two populations were defined as the genomic regions associated with trait convergence,and the parallel selection signatures related to important economic traits of pigs were explored based on these putative regions.【Result】 The results showed that 5 112 selection signatures with a total length of 487.51 Mb and 9 579 selection signatures with a total length of 913.50 Mb were detected by iHS and △AF,respectively.After merging the close region,a total of 52 parallel selection regions with the length of approximately 4.67 Mb were found,88 candidate genes were annotated to be related to the traits such as reproduction,carcass and meat quality.【Conclusion】 A total of 52 genomic selection regions might be associated with trait convergence between Pietrain and Duroc pigs,the parallel selection signatures were mainly involved in economically important traits such as reproduction,carcass and meat quality,which was related to the similar breeding direction of lean pigs,and the identification of these key genes could provide a reference for the genetic improvement of subsequent commercial pig breeds.

Key words: Pietrain pigs; Duroc pigs; genetic improvement; trait convergence; selection signature; genome

CLC Number:

S813.3

LI Wangjiao, PENG Xia, SONG Hui, DONG Wenjun, LI Xinyun, ZHAO Shuhong, MA Yunlong. Selection Signature Analysis Reveals the Key Genes Associated with the Convergence Traits Among Porcine Terminal Sire Populations[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(8): 2982-2991.

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Selection Signature Analysis Reveals the Key Genes Associated with the Convergence Traits Among Porcine Terminal Sire Populations

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