microRNA let-7调控动物个体发育的研究进展

doi:10.16431/j.cnki.1671-7236.2015.02.016

Abstract

Abstract: microRNAs (miRNAs) are evolutionary conserved small noncoding RNAs of 18 to 25 nt that were found in all metazoans,and it regulates gene expression by base pairing with their target mRNA,leading to mRNA cleavage or translational repression.let-7 is a small RNA molecule originally found in worms,and it is highly conserved and plays a vital role in posttranscriptional regulation.The study found that let-7 takes part in the development of organs and tissues.This review summarized the recent progresses about the function of let-7 miRNA in the development of brain,nervous system,lung and cardiovascular system,and muscle development,and elucidated the possible mechanism of regulating the developmental processes of animal tissues and organs.It will provide the basis for further exploring the function of let-7 miRNA in animals.

Key words: microRNA; let-7; individual development; tissue and organ

CLC Number:

Q522

ZHAO Shuan-ping, JIA Yu-tang, XU Lei, RUAN Yong-ming. Progress of Animal Individual Development Regulated by microRNA Let-7[J]. , 2015, 42(2): 342-346.

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Progress of Animal Individual Development Regulated by microRNA Let-7

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