microRNA与病毒关系研究进展

doi:10.16431/j.cnki.1671-7236.2015.11.016

Abstract

Abstract: microRNAs is a class of small non-coding RNA,whose size is 20 to 22 nucleotides and widely exist in eukaryotic cells.It makes the target gene degradation or translation blocked by completely or incompletely complementary with the 3'UTR of target mRNA.microRNA involve in the expression of many genes,refer to cell differentiation,development,apoptosis,viral infection,immunity,metabolism,tumor and so on many processes of life.The relationship between microRNA and virus is complicated,microRNA encoded by host cells can control the gene itself or virus so as to affect the virus infection,microRNA encoded by virus also can control the gene itself or host cells so as to affect the virus infection,the virus can also influence the formation and fuction of host microRNA.To clarify the relationship between microRNA and virus will help researchers to explore new ideas,to better carry out the related research work,to provide theoretical support for scientific researches.Therefore,the author reviewed microRNA discovery and naming,formation,function mechanism and the current new view of the interrelation between microRNA and virus.

Key words: microRNA; virus; function mechanism; interrelation

CLC Number:

S851

HU Ren-jun, TU Li-qing, LI Shou-jun. Research Progress on Relationship between microRNA and Virus[J]. , 2015, 42(11): 2921-2927.

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