microRNA与病毒关系研究进展

doi:10.16431/j.cnki.1671-7236.2015.11.016

Abstract

Abstract: microRNAs is a class of small non-coding RNA,whose size is 20 to 22 nucleotides and widely exist in eukaryotic cells.It makes the target gene degradation or translation blocked by completely or incompletely complementary with the 3'UTR of target mRNA.microRNA involve in the expression of many genes,refer to cell differentiation,development,apoptosis,viral infection,immunity,metabolism,tumor and so on many processes of life.The relationship between microRNA and virus is complicated,microRNA encoded by host cells can control the gene itself or virus so as to affect the virus infection,microRNA encoded by virus also can control the gene itself or host cells so as to affect the virus infection,the virus can also influence the formation and fuction of host microRNA.To clarify the relationship between microRNA and virus will help researchers to explore new ideas,to better carry out the related research work,to provide theoretical support for scientific researches.Therefore,the author reviewed microRNA discovery and naming,formation,function mechanism and the current new view of the interrelation between microRNA and virus.

Key words: microRNA; virus; function mechanism; interrelation

CLC Number:

S851

HU Ren-jun, TU Li-qing, LI Shou-jun. Research Progress on Relationship between microRNA and Virus[J]. China Animal Husbandry & Veterinary Medicine, 2015, 42(11): 2921-2927.

References

[1] Thomson J M,Newman M,Parker J S,et al.Extensive post-transcriptional regulation of microRNAs and its implications for cancer[J].Genes & Development,2006,20(16):2202-2207.
[2] Bartel D P.microRNAs:Genomics,biogenesis,mechanism,and function[J].Cell,2004,116(2):281-297.
[3] Ambros V.microRNAs:Tiny regulators with great potential[J].Cell,2001,107(7):823-826.
[4] Song L,Tuan R S.microRNAs and cell differentiation in mammalian development[J].Birth Defects Research Part C Embryo Today,2006,78(2):140-149.
[5] Lee R C,Feinbaum R L,Ambros V.The C.elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J].Cell,1993,75(5):843-854.
[6] Reinhart B J,Slack F J,Basson M,et al.The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans[J].Nature,2000,403(6772):901-906.
[7] 王晓曈,谢婷,李翼飞,等.microRNA与肺部疾病[J].国际病理科学与临床杂志,2011,31(5):457-460.
[8] Lee Y,Jeon K Y,Lee J,et al.microRNA maturation:Stepwise processing and subcellular localization[J].EMBO J,2002,21(17):4663-4670.
[9] Hutvagner G,Zamore P D.A microRNA in a multiple-turnover RNAi enzyme complex[J].Science,2002,297(5589):2056-2060.
[10] 金吉春,金星林.microRNA的概述及其研究[J].医学研究生学报,2013,26(10):1109-1112.
[11] 王杰,边艳杰,王卓然,等.microRNA-152对奶牛乳腺上皮细胞乳蛋白合成的调控作用[J].中国畜牧兽医,2014,41(6):6-10.
[12] 张抒,张强,张萌,等.miRNA对乳腺发育及泌乳调节作用的研究进展[J].中国畜牧兽医,2015,42(3):663-667.
[13] Lee I,Ajay S S,Yook J I,et al.New class of microRNA targets containing simultaneous 5'UTR and 3'UTR interaction sites[J].Genome Research,2009,19(5):1175-1183.
[14] Schnall-Levin M,Rissland O S,Johnston W K,et al.Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs[J].Genome Research,2011,21(9):1395-1403.
[15] Schnall-Levin M,Zhao Y,Perrimon N,et al.Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs[J].PNAS,2010,107(36):15751-15756.
[16] Qin W,Shi Y,Zhao B,et al.miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of faf1 in cancer cells[J].PLoS One,2010,5(2):e9429.
[17] Forman J J,Coller H A.The code within the code:microRNAs target coding regions[J].Cell Cycle,2010,9(8):1533-1541.
[18] Khorshid M,Hausser J,Zavolan M,et al.A biophysical miRNA mRNA interaction model infers canonical and noncanonical targets[J].Nature Methods,2013,10(3):253-255.
[19] Pfeffer S,Zavolan M,Grässer F A,et al.Identification of virus-encoded microRNAs[J].Science,2004,304(5671):734-736.
[20] Sarkies P,Ashe A,Le Pen J,et al.Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans[J].Genome Research,2013,23(8):1258-1270.
[21] Veksler-Lublinsky I,Shemer-Avni Y,Kedem K,et al.Gene bi-targeting by viral and human miRNAs[J].BMC Bioinformatics,2010,11:249.
[22] Skalsky R L,Cullen B R.Viruses,microRNAs,and host interactions[J].Annu Rev Microbiol,2010,64:123-141.
[23] Libri V,Miesen P,van Rij R P,et al.Regulation of microRNA biogenesis and turnover by animals and their viruses[J].Cellular and Molecular Life Sciences,2013,70(19):3525-3544.
[24] Song L,Liu H,Gao S,et al.Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells[J].Journal of Virology,2010,84(17):8849-8860.
[25] Li J,Kao K,Li L,et al.microRNA-145 regulates oncolytic herpes simplex virus-1 for selective killing of human non-small cell lung cancer cells[J].Virology Journal,2013,10:241.
[26] Wang D,Cao L,Xu Z,et al.miR-125b reduces porcine reproductive and respiratory syndrome virus replication by negatively regulating the NF-κB pathway[J].PLoS One,2013,8(2):e55838.
[27] Thounaojam M C,Kundu K,Kaushik D K,et al.microRNA 155 regulates Japanese encephalitis virus-induced inflammatory response by targeting Src homology 2-containing inositol phosphatase 1[J].Journal of Virology,2014,88(9):4798-4810.
[28] Zheng Z,Ke X,Wang M,et al.Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome[J].Journal of Virology,2013,87(10):5645-5656.
[29] Huang T,Zhang X.Functional analysis of a crustacean microRNA in host-virus interactions[J]. Journal of Virology,2012,86(23):12997-13004.
[30] Slonchak A,Hussain M,Torres S,et al.Expression of mosquito microRNA Aae-miR-2940-5p is downregulated in response to west nile virus infection to restrict viral replication[J].Journal of Virology,2014,88(15):8457-8467.
[31] Li Y,Chan E Y,Li J,et al.microRNA expression and virulence in pandemic influenza virus-infected mice[J].Journal of Virology,2010,84(6):3023-3032.
[32] Meliopoulos V A,Andersen L E,Brooks P,et al.microRNA regulation of human protease genes essential for influenza virus replication[J].PLoS One,2012,7(5):e37169.
[33] Chen Y,Chen J,Wang H,et al.HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1[J].PLoS Pathogens,2013,9(4):e1003248.
[34] Stewart C R,Marsh G A,Jenkins K A,et al.Promotion of Hendra virus replication by microRNA 146a[J].Journal of Virology,2013,87(7):3782-3791.
[35] O'Connor C M,Vanicek J,Murphya E A.Host microRNA regulation of human cytomegalovirus immediate early protein translation promotes viral latency[J].Journal of Virology,2014,88(10):5524-5532.
[36] Mahajan V S,Drake A,Chen J.Virus-specific host miRNAs:Antiviral defenses or promoters of persistent infection[J].Trends Immunol,2009,30(1):1-7.
[37] Kamel W,Segerman B,Oberg D,et al.The adenovirus VA RNA-derived miRNAs are not essential for lytic virus growth in tissue culture cells[J].Nucleic Acids Res,2013,41(9):4802-4812.
[38] Bogerd H P,Skalsky R L,Kennedy E M,et al.Replication of many human viruses is refractory to inhibition by endogenous cellular microRNAs[J].Journal of Virology,2014,88(14):8065-8076.
[39] Rouha H,Thurner C,Mandl C W.Functional microRNA generated from a cytoplasmic RNA virus[J].Nucleic Acids Research,2010,38(22):8328-8337.
[40] Shapiro J S,Varble A,Pham A M,et al.Noncanonical cytoplasmic processing of viral microRNAs[J].RNA,2010,16(11):2068-2074.
[41] Varble A,Chua M A,Perez J T,et al.Engineered RNA viral synthesis of microRNAs[J].PNAS,2010,107(25):11519-11524.
[42] Varble A,Tenoever B R.Implications of RNA virus-produced miRNAs[J].RNA Biology,2011,8(2):190-194.
[43] Shapiro J S,Langlois R A,Pham A M,et al.Evidence for a cytoplasmic microprocessor of Pri-miRNAs[J].RNA,2012,18(7):1338-1346.
[44] Shapiro J S,Schmid S,Aguado L C,et al.Drosha as an interferon-independent antiviral factor[J].PNAS,2014,111(19):7108-7113.
[45] Singh C P,Singh J,Nagaraju J.A baculovirus-encoded microRNA (miRNA) suppresses its host miRNA biogenesis by regulating the exportin-5 cofactor ran[J].Journal of Virology,2012,86(15):7867-7879.
[46] Huang T,Cui Y,Zhang X.Involvement of viral microRNA in the regulation of antiviral apoptosis in shrimp[J].Journal of Virology,2014,88(5):2544-2554.
[47] Holland B,Wong J,Li M,et al.Identification of human microRNA-like sequences embedded within the protein-encoding genes of the human immunodeficiency virus[J]. PLoS One,2013,8(3):e58586.
[48] Broekema N M,Imperiale M J.miRNA regulation of BK polyomavirus replication during early infection[J].PNAS,2013,110(20):8200-8205.
[49] Ramalingam D,Kieffer-Kwon P,Ziegelbauer J M.Emerging Themes from EBV and KSHV microRNA targets[J].Viruses,2012,4(9):1687-1710.
[50] He Y,Yang K,Zhang X.Viral microRNAs targeting virus genes promote virus infection in shrimp in vivo[J].Journal of Virology,2014,88(2):1104-1112.
[51] Nukui M,Mori Y,Murphya E A.A human herpesvirus 6A-encoded microRNA:Role in viral lytic replication[J].Journal of Virology,2015,89(5):2615-2627.
[52] Jung Y,Choi H,Kim H,et al.microRNA miR-BART20-5p stabilizes epstein-barr virus latency by directly targeting BZLF1 and BRLF1[J].Journal of Virology,2014,88(16):9027-9037.
[53] Sung C K,Yim H,Andrews E,et al.A mouse polyomavirus-encoded microRNA targets the cellular apoptosis pathway through Smad2 inhibition[J].Virology,2014,468-470:57-62.
[54] Barichievy S,Naidoo J,Mhlanga M M.Non-coding RNAs and HIV:Viral manipulation of host dark matter to shape the cellular environment[J].Frontiers in Genetics,2015,6:108.
[55] Hsu C,Yi Y,Chang K,et al.The epstein-barr virus-encoded microRNA miR-BART9 promotes tumor metastasis by targeting E-cadherin in nasopharyngeal carcinoma[J].PLoS Pathogens,2014,10(2):e1003974.
[56] Hook L M,Grey F,Grabski R,et al.Cytomegalovirus miRNAs target secretory pathway genes to facilitate formation of the virion assembly compartment and reduce cytokine secretion[J].Cell Host Microbe,2014,15(3):363-373.
[57] Li C,Hu J,Hao J,et al.Competitive virus and host RNAs:The interplay of a hidden virus and host interaction[J].Protein Cell,2014,5(5):348-356.
[58] Bivalkar-Mehla S,Vakharia J,Mehla R,et al.Viral RNA silencing suppressors (RSS):Novel strategy of viruses to ablate the host RNA interference (RNAi) defense system[J].Virus Res,2011,155(1):1-9.
[59] Thornburg N J,Hayward S L,Crowe J E Jr.Respiratory syncytial virus regulates human microRNAs by using mechanisms involving beta interferon and NF-κB[J].MBio,2012,3(6):e212-e220.
[60] Backes S,Shapiro J S,Sabin L R,et al.Degradation of host microRNAs by poxvirus poly(A) polymerase reveals terminal RNA methylation as a protective antiviral mechanism[J].Cell Host Microbe,2012,12(2):200-210.
[61] Mansouri S,Pan Q,Blencowe B J,et al.Epstein-barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and Dicer[J].Journal of Virology,2014,88(19):11166-11177.
[62] Li C H,Xu F,Chow S,et al.Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression[J].European Journal of Cancer,2014,50:2560-2569.
[63] Zhang X D,Wang Y,Ye L H.Hepatitis B virus X protein accelerates the development of hepatoma[J].Cancer Biol Med,2014,11:182-190.

Research Progress on Relationship between microRNA and Virus

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	HUANG Xiaojiu, LEI Lei, PENG Xiaoye, WANG Kaixin, CHEN Yingyi, WANG Jixian, WANG Yuge, DUAN Deyong, YANG Yi, WANG Aibing. Construction of a IPEC-J2 Cell Line Stably Overexpressing NM-ⅡA Tail and Its Effect on Porcine Epidemic Diarrhea Virus Infection [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2243-2252.
[2]	WU Peng, YUAN Yang, YANG Yunyun, FENG Yi, WANG Yan, YANG Ying, CHEN Jiangfeng, JIANG Haibo, WEN Ming. Diagnosis and Pathogen Identification of a Case of Mixed Infection of Duck Plague Virus and Pasteurella multocida in Breeding Goose [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2253-2265.
[3]	WU Yue, SHI Xingya, ZHANG Shuai, ZHAO Yunhuan, GUO Liming, ZUO Yuzhu, FAN Jinghui. Isolation and Identification of Porcine Pseudorabies Virus and Genetic Evolution Analysis of gE and gC Genes [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2266-2277.
[4]	JIAO Xianqin, MA Xiao, TIAN Runbo, LIU Ying, MA Shijie, CHEN Hongying. Construction of Recombinant Porcine Pseudorabies Virus Expressing Cap Protein of Porcine Circovirus Type 2d [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2278-2286.
[5]	LIU Min, CHENG Huai, ZHENG Zhenzhen, ZHANG Mengsi, ZHANG Hewei, REN Jingqiang. Eukaryotic Expression and Polyclonal Antibody Preparation of N Protein of Canine Parainfluenza Virus [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(5): 2287-2294.
[6]	SI Wei, TAN Xiyu, XU Lingyun, LUO Tingrong, LI Xiaoning, GU Jinyan. Prokaryotic Expression of HA1 Protein of Swine Influenza Virus Subtype H3N2 and Preparation of Polyclonal Antibodies [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1739-1749.
[7]	CHEN Zuoxin, CHEN Yuxin, PAN Yanlin, HUANG Yunzhen, LI Linlin, DONG Jiawen, XIANG Yong, XU Zhihong, SUN Minhua, ZHANG Junqin, HUANG Shujian, LIAO Ming. Isolation,Identification and Pathogenicity of Two Strains of Cluster 3 Goose Tembusu Virus [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1750-1762.
[8]	MIAO Shukui, MI Xiaoyun, WEI Jie, WEI Yurong, HAILIQIEMU·Maimaitiyiming. Cloning and Bioinformatics Analysis of VP7 Gene of the Genotype G8 Bovine Rotavirus [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1784-1795.
[9]	WANG Linqing, ZHANG Liuhui, CHEN Ximeng, MA Shijie, SONG Yue, CHEN Hongying. Construction and Biological Characteristics of Recombinant PRV in Partial Epitope Region of CSFV E2 Gene [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1815-1824.
[10]	GUO Qianqian, TANG Yuqing, QI Zhenchang, LI Qinghao, JIN Xin, MA Junxing, SUN Juan. Research Progress on Isolation and Culture of Tracheal Epithelial Cells and Their Role in Respiratory Coronaviruses Infection [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(4): 1836-1843.
[11]	PAN Xiangying, ZENG Zhiyong, LIANG Haiying, TANG Deyuan, WANG Bin, YE Ni, TIAN Hongli, BIAN Mengting, LIU Jiajia, HUANG Shu. Truncated Expression of Porcine Rotavirus VP6 Protein and Establishment of an Indirect ELISA Antibody Detection Method [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1231-1240.
[12]	LIN Weishan, MA Doudou, LEI Mengtong, WEI Bin, LI Guocai, WANG Guanghua, WANG Geping, JIAN Yingna, LI Xiuping. Epidemiological Investigation and Genetic Evolution Analysis of 5'-UTR of Bovine Viral Diarrhea Virus in Yaks in Haibei，Qinghai Province [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1241-1249.
[13]	LI Haiyang, GAO Yongyu, LI Hanwen, FENG Hongsheng, XIAN Yuhan, YANG Siyu, SANG Chenjun, CAO Yudie, TANG Yue, LI Zibin, GAO Fengshan. Research Progress on the Mechanism of Foot-and-mouth Disease Virus Proliferation and Immune Evasion in Host Cells [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1250-1262.
[14]	DING Ding, DING Xiaojun, MUSA Rehman, ZHEN Jie, SALAMAITI Srajiding, LI Na, SUN Yawei, CHEN Rulong, YAO Gang, MA Xuelian. Analysis on Viral Pathogen Detection and Epidemic Characteristics of Calf Diarrhea in Some Large-scale Cattle Farms in Xinjiang [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1272-1280.
[15]	MAO Fuchao, ZHAI Chongkai, TIAN Wenjing, WANG Conghui, SONG Minjie, WANG Yingxian, ZHANG Hewei. An Updated Review of Porcine Deltacoronavirus in Terms of Infection and Anti-infection Research [J]. China Animal Husbandry & Veterinary Medicine, 2025, 52(3): 1281-1291.