绿壳蛋鸡与白来航蛋鸡microRNA变异及其靶基因预测分析

doi:10.16431/j.cnki.1671-7236.2016.06.003

Abstract

Abstract: The study was conducted to explore the potential different characters between Blue-shelled chicken and White leghorn.Global genome microRNA was combined the identified microRNA with complementary lab-predicted microRNA.Then the two breed chicken's SNP data got by GGRS were mapped to the microRNA and focused on SNP that deliberately located in mature-microRNA.Bioinformatics method was adopted for target prediction on microRNA which had SNPs.By further gene enrichment analysis,the study found these genes enriched in 22 GO terms,10 KEGG pathways,and 3 IPA important networks.And they enriched in traits which associated with growth,such as mTOR signaling pathways,Wnt signaling pathways,growth hormone receptor networks and insulin-like growth factor Ⅰ receptor networks.And they also enriched in some laying traits,such as oocyte meiotic signaling pathways and progesterone mature oocytes signaling pathways.The methods and the results might provide references for further studies.

Key words: Blue-shelled chicken; White leghorn; microRNA; SNP; target genes prediction; enrichment analysis

CLC Number:

S831

GUAN Yu-yu, LIAO Rong-rong, WANG Zhen, ZHAO Jing, CHEN Zhen-liang, ZHANG Zhe, XIAO Qian, SUN Hao, WANG Qi-shan, ZHANG Xiang-zhe, YANG Chang-suo, PAN Yu-chun. Analysis on Target Genes with Mutation in microRNA of Blue-shelled Chicken and White Leghorn[J]. , 2016, 43(6): 1413-1421.

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Analysis on Target Genes with Mutation in microRNA of Blue-shelled Chicken and White Leghorn

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