新型兽用纳米乳载药系统在大鼠体内的药代动力学研究

doi:10.16431/j.cnki.1671-7236.2019.04.033

Abstract

Abstract:

To study the pharmacokinetics behavior of florfenicol nanoemulsion in rats,florfenicol solution was chosen as the contrast medicine,the medicine was taken oral and intramuscular dose of 30 mg/kg body weight,and sampled at 0.5,1,2,4,8,12,24,36,48 and 72 h.The concentrations of florfenicol in plasma samples were detected by a high performance liquid chromatography (HPLC) method.The data were analyzed with the pharmacokinetic program DAS 2.0.The results showed that the concentration-time course of florfenicol solution and florfenicol nanoemulsion in plasma fitted a 2-compartment open model.The parameters of FFNE and FFSol under compartmental model after oral administration,AUC_(0-∞) were 1 085.047 and 2 176.490 mg/L·h,half-life were 10.566 and 13.687 h,the relative bioavailability of florfenicol nanoemulsion was 187.4%.The parameters of FFNE and FFSol under compartmental model after intravenous administration,AUC_(0-∞) were 1 530.55 and 3 243.338 mg/L·h respectively,the half-life were 7.533 and 13.335 h,respectively,and the relative bioavailability of florfenicol nanoemulsion was 211.9%.The results indicated that FFNE had an adequate distribution in rats after intramscular and oral administration,however,elimination rate was faster by oral administration than by intramuscular of most rats.The prepared florfenicol nanoemulsion promoted absorption of florfenicol,and the bioavailability of florfenicol nanoemulsion was significantly improved.

Key words: florfenicol; nanoemulsion; pharmacokinetic; bioavailability

CLC Number:

S859.79

SHI Feifei, WANG Jing, QIN Feng, CHEN Xiaolan, GAO Jianru, WEI Yu, ZHANG Long. Study on Pharmacokinetics of a Novel Veterinary Nanoemulsion Drug Loading System in Rats[J]. , 2019, 46(4): 1236-1243.

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Study on Pharmacokinetics of a Novel Veterinary Nanoemulsion Drug Loading System in Rats

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