环糊精包合氟苯尼考在猪体内的药代动力学研究

doi:10.16431/j.cnki.1671-7236.2020.06.033

Abstract

Abstract: In order to evaluate the bioequivalence of flufenicol (test reagent F) produced by the new coating process with the similar foreign products (R1) and domestic products (R2),and to explore its pharmacokinetic characteristics in pigs.The design of random triplet and triplet self-crossing test was adopted.Six healthy castrated male pigs (15 kg±2 kg) were respectively to take three formulations by oral administration (20 mg/kg).Flufenicol plasma concentration was analyzed by high performance liquid chromatography.Pharmacokinetic characteristics were analyzed by Kinetica 5.0,and bioequivalence was evaluated by SAS statistical software.The results showed that the drug time curve of the tested preparation in pigs conformd to the first-order absorption one-chamber open model.The C_max of F,R1 and R2 were 16.0845,18.3287 and 21.1678 μg/mL respectively,T_max were 5.0,1.9 and 1.5 h respectively;AUC_0-∞ were 144.7327,118.2670 and 123.3715 μg/mL·h,respectively.The relative bioavailability of the two reference preparations was 122.51% (R1) and 117.52% (R2),respectively.The results showed that cyclodextrin coated with flurbenicol had better sustained-release effect,better biosafety,longer duration of efficacy,and higher bioavailability.

Key words: cyclodextrin inclusion flurbenicol; pig; high performance liquid chromatography; pharmacokinetics; bioequivalence

CLC Number:

S859.79

ZHANG Le, ZHANG Guangfeng, ZHU Chongmiao, WU Zhi, ZHU Shanyuan, YU Shenglan, FENG Qi, XING Xiaoling, ZHAO Qiannan. Study on Pharmacokinetics of Cyclodextrin-encapsulated Flufenicol in Pigs[J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(6): 1934-1941.

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Study on Pharmacokinetics of Cyclodextrin-encapsulated Flufenicol in Pigs

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