四逆汤加减对仔猪腹泻治疗效果研究

doi:10.16431/j.cnki.1671-7236.2023.04.041

Abstract

Abstract: 【Objective】 This study was aimed to explore the therapeutic effect of Sini decoction on piglet diarrhea and the influence of growth performance,blood physiological and biochemical indicators and intestinal flora.【Method】 One hundred and twenty 3-day-old diarrhea piglets with similar body weight were randomly divided into Chinese medicine group and Western medicine group,with 60 piglets in each group, and 60 healthy piglets of the same group were seleted as blank control group.The piglets in Chinese medicine group were fed with 5 g modified Sini decoction compound Chinese medicine solution every day for 7 days,while those in Western medicine group were injected intramuscularly with 0.1 mg/kg BW of gentamicin once a day for 4 days,blank control group was not treated with drugs.The mental status,food intake,diarrhea and average daily weight gain were recorded during the treatment period,and the blood physiological and biochemical indexes and intestinal microflora were determined before and after treatment.【Result】 After 5 days of treatment,the cure rate in traditional Chinese medicine group was 97%,which was significantly higher than that in Western medicine group(87%) (P＜0.05),and no death occurred.After the treatment,the average daily gain of piglets in traditional Chinese medicine group was significantly higher than that in Western medicine and blank control groups (P＜0.05).The results of blood routine test showed that the amount of white blood cell (WBC),lymphocyte (LYM),mononuclear cell (MONO),neutrophil (GRAN) and hematocrit (HCT) in traditional Chinese medicine group were significantly higher than those in Western medicine group (P＜0.05).There was no significant difference in other blood routine indicators between groups (P＞0.05).The blood biochemical results showed that the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in traditional Chinese medicine group were significantly lower than those in Western medicine group (P＜0.05),the creatinine (CRE) content was significantly higher than that of Western medicine group (P＜0.05),there was no significant difference between traditional Chinese medicine and blank control groups (P＞0.05).High-throughput sequencing of intestinal flora showed that, compared with Western medicine group, the Simpson and Shannon indexes of intestinal flora in traditional Chinese medicine group were significantly higher (P＜0.05), and the abundance of Firmicutes and Bacteroides, Lactobacillus and Clostridium were increased,the abundance of Proteobacteria and Fusobacteria, E.coli,Bacillus and Enterococcus were decreased.【Conclusion】 Modified Sini decoction could effectively treat diarrhea piglets,and the effect was better than Western medicine group,and could effectively improve the growth performance of diarrhea piglets,promote the body damage repair,adjust the structure of intestinal flora.

Key words: piglet diarrhea; Sini decoction; treatment effect

CLC Number:

S859.3

YANG Zhi, YU Jiaxin, YANG Linfu, WANG Kang, LI Guanzong, DUAN Gang, YANG Fumei, LIU Zhiqi, ZHOU Ke, HE Jun, DAI Feiyan. Study on the Therapeutic Effect of Modified Sini Decoction on Piglet Diarrhea[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(4): 1707-1717.

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Study on the Therapeutic Effect of Modified Sini Decoction on Piglet Diarrhea

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