抗仔猪腹泻产肠毒素大肠杆菌疫苗的研究进展

doi:10.16431/j.cnki.1671-7236.2015.02.017

Abstract

Abstract: Piglet diarrhea is one of the most challenging problems what swine industry has faced at home and abroad,which causes a huge economic loss annually.Enterotoxigenic Escherichia coli (ETEC) is the main pathogenic bacteria of piglet diarrhea,whose pathogenicity depends on the co-effect of adhesion and enterotoxin.As the research methods innovate,the researchers at home and abroad have got important breakthroughs in the development of ETEC vaccines.This article introduced the pathogenic characters of ETEC,and summarized the progress on the development of all kinds of vaccines against ETEC.

Key words: enterotoxigenic Escherichia coli (ETEC); vaccine; piglet diarrhea; adhesion; enterotoxin

CLC Number:

S857.3⁺1

ZHANG Heng-hui, YOU Jian-song, XU Yong-ping, WANG Xiao-li, LI Xiao-yu. Research Progress on ETEC Vaccines against Piglet Diarrhea[J]. , 2015, 42(2): 347-351.

References

[1] 杨正时.动物病原性大肠杆菌与大肠杆菌病[J].中国兽医科技,1987,6:25-29.
[2] 王春江,赵献军,赵宝,等.陕西省致仔猪腹泻ETEC的分子流行病学调查[J].西北农林科技大学学报(自然科学版),2010,38(7):21-26.
[3] 周庆雨,陆春权,王建,等.连云港地区仔猪腹泻的病因学调查[J].中国兽医杂志,2010,46(9):30-31.
[4] 房海.大肠埃希氏菌[M].石家庄:河北科学技术出版社,1997.
[5] Falkow S.Molecular Koch's postulates applied to microbial pathogenicity[J].Reviews of Infectious Diseases,1988,10(Suppl2):S274-S276.
[6] Fleckenstein J M,Hardwidge P R,Munson G P,et al.Molecular mechanisms of enterotoxigenic Escherichia coli infection[J].Microbes Infect, 2010,12(2):89-98.
[7] Zhou M X,Duan Q D.Both flagella and F4 fimbriae from F4ac⁺ enterotoxigenic Escherichia coli contribute to attachment to IPEC-J2 cells in vitro[J].Veterinary Research,2013,44(1):30.
[8] Roy K,Hamilton D J,Fleckenstein J M.Fleckenstein.Cooperative role of antibodies against heat-labile toxin and the EtpA adhesin in preventing toxin delivery and intestinal colonization by enterotoxigenic Escherichia coli[J]. Clinical and Vaccine Immunology,2012,19(10):1603-1608.
[9] Shepard S M,Danzeisen J L,Isaacson R E,et al.Genome sequences and phylogenetic analysis of K88- and F18-positive porcine enterotoxigenic Escherichia coli[J].Journal of Bacteriology,2012, 194(2):395-405.
[10] Daudelin J F,Lessard M,Beaudoin F,et al.Administration of probiotics influences F4 (K88)-positive enterotoxigenic Escherichia coli attachment and intestinal cytokine expression in weaned pigs[J].Veterinary Research,2011,42(1):69.
[11] Coddens A,Valis E,Benktander J,et al.Erythrocyte and porcine intestinal glycosphingolipids recognized by F4 fimbriae of enterotoxigenic Escherichia coli[J].PLoS One,2011,6(9):e23309.
[12] Ren J,Yan X M.Susceptibility towards enterotoxigenic Escherichia coli F4ac diarrhea is governed by the MUC13 gene in pigs[J].PLoS One,2012,7(9):e44573.
[13] 王多福,魏玉明,冯国廷.仔猪大肠杆菌灭活苗的研制及效果观察[J].中国动物检疫,2000,17(5):29-30.
[14] 陈希文,郭晓萍,王雄清,等.猪大肠杆菌绵阳分离株灭活疫苗的制备及对小鼠的免疫原性研究[J].江苏农业科学,2009,6:289-291.
[15] 李鹏,王家乡,程碧军.仔猪黄痢K88-K99-987p-F41多价菌毛疫苗的制备及小鼠免疫试验[J].动物医学进展,2006,27(9):55-58.
[16] Klipstein F A,Engert R F,Clements J D,et al.Development of a vaccine of cross-linked heat-stable and heat-labile enterotoxins that protects against E.coli either enterotoxin[J].Infect Immun,1982,37(2):550-557.
[17] Frantz J C, Bhatnagar P K, Brown A L, et al.Investugation of synthetic Escherichia coli heat-stable enterotoxin as an immunogen for swine and cattle[J].Infect Immun,1987,55(5):1077-1084.
[18] 王劼.产肠毒素大肠杆菌菌毛的DNA疫苗研究进展[J].中国畜牧兽医,2011,38(2):178-181.
[19] 张景六,蔡瑞珠,洪孟民.带有K88与K99两种伞毛抗原基因的重组质粒的构建[J].生物工程学报,1985,1(2):34-40.
[20] 刘兴汉,王莉林,初晓白,等.K₈₈、K₉₉、F₄₁三价基因工程菌的构建[J].中国畜禽传染病,1991,6:46-49.
[21] 陈章水,崔溢洙,原魁章,等.表达K₈₈K₉₉双纤毛抗原及K₉₉纤毛抗原的产肠毒素大肠杆菌的构建[J].中国畜禽传染病,1992,5:37-42.
[22] Clements J D.Construction of anontoxic fusion peptide for immunization against Escherichia coli strains that produce heat-labile and heat-stable enterotoxin[J].Infect Immun,1990,58(5):1159-1166.
[23] 张兆山,李淑琴,黄翠芬.CFA/1结构基因的核苷酸序列测定及其重组克隆的电镜观察[J].生物工程学报,1993,9(1):43-47.
[24] 倪艳秀,何孔旺,俞正玉,等.肠毒素性大肠杆菌mSTⅠ-linker-LTB融合蛋白的表达及免疫保护试验[J].农业生物技术学报,2007,15(3):383-387.
[25] 许崇波,卫广森,王卓,等.大肠杆菌肠毒素ST₁-LT_B融合基因的高效表达[J].卫生研究,1998,17(S1):15-18.
[26] You J,Xu Y,He M,et al.Protection of mice against enterotoxigenic E.coli by immunization with a polyvalent enterotoxin comprising a combination of LTB,STa,and STb[J].Appl Microbiol Biotechnol,2011,89(6):1885-1893.
[27] 尤建嵩.产肠毒素大肠杆菌多价肠毒素疫苗的研究[D].大连:大连理工大学,2011.
[28] 李丰生,陈添弥,黄翠芬.用遗传工程技术构建含E.coli K88ac和LT(A^-B⁺)两种抗原基因的菌株[J].生物工程学报,1987,3(2):102-107.
[29] 韩文瑜,黎诚耀,梁焕春,等.大肠杆菌K_88ac与LT(A^-B⁺)抗原基因质粒在猪霍乱沙门氏菌弱毒株中的表达[J].兽医大学学报,1992,12(1):7-10.
[30] 许崇波,冯书章,刘子,等.大肠杆菌耐热性肠毒素Ⅰ基因核苷酸序列分析与免疫原性研究[J].中国兽医学报,1996,16(4):16-21.
[31] 许崇波,卫广森.表达大肠杆菌K88ac-ST₁-LT_B融合蛋白基因工程菌株的构建[J].生物工程学报,2002,18(2):216-220.
[32] 孔庆军,任雪艳,李卓夫.大肠杆菌黏附素蛋白与热稳定肠毒素融合基因植物表达载体的构建[J].家畜生态学报,2005,26(4):16-19.

Research Progress on ETEC Vaccines against Piglet Diarrhea

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