疯草解毒复方中药制剂的药代动力学研究

doi:10.16431/j.cnki.1671-7236.2016.06.023

Abstract

Abstract: The test was conducted to study the pharmacokinetics of compound traditional Chinese medicine preparation for locoweed detoxication in rats.After oral drug preparations,the absorption circumstances of active ingredients in vivo were detected by ultraviolet spectrophotometry and then the relative pharmacokinetic parameters were calculated based on identifying the effective components.The results showed that a suitable ultraviolet spectrum analytical method was established for 8 compounds at first.It had shown that the effective components were absorbed into the blood quickly after oral administration,and the maximum plasma concentration of each composition was got after about 1 h,indicating that the efficacy developed rapidly.The metabolic rates of Codonopsis pilosula saponin,polysaccharide and ferulic acid were fast,while the action time of the metabolites of glycyrrhizic acid,saikosaponin,astraloside and prim-O-glucosylc-imifugin were longer.The results suggested that pharmacolinetic process of this medicine preparation in rats basically conformed with two compartment model (expect the hesperidin).The determination method was simple,and had high accuracy and stability,as well as suitable for the pharmacokinetic study.

Key words: compound traditional Chinese medicine preparation; pharmacokinetics; UV spectrophotometry; locoweed

CLC Number:

S859.7

HAO Bao-cheng, QUAN Xiao-di, YE Yong-li, GAO Xu-dong, HUANG Xin, WANG Xue-hong, LIU Jian-zhi, WANG Bao-hai, LIANG Jian-ping. Study on Pharmacokinetics of Compound Traditional Chinese Medicine Preparation for Locoweed Detoxication[J]. , 2016, 43(6): 1550-1556.

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Study on Pharmacokinetics of Compound Traditional Chinese Medicine Preparation for Locoweed Detoxication

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