盐酸头孢噻呋注射液在猪体内的比较药动学研究

doi:10.16431/j.cnki.1671-7236.2021.04.036

Abstract

Abstract: In this study,the pharmacokinetic (PK) of ceftiofur hydrochloride injection in healthy pigs and infected pigs with pasteurellosis was studied by lung bronchialperfusion technique.Twelve piglets were randomly averagely divided into healthy and infection groups.The infection group was artificially infected with Pasteurella multocida to establish the disease model.Two groups of pigs were intramuscularly injected with ceftiofur hydrochloride injection according to the cross-experiment design.Blood and bronchoalveolar lavage fluid (BALF) were collected at different time points,and the drug content was detected by HPLC.The main PK parameters in plasma and BALF of healthy pigs were as follows:Drug peak concentration (C_max) were 22.33 and 2.49 μg/mL,respectively,the difference was nearly 9 times;Elimination half-life (T_1/2) were 19.51 and 70.19 h,respectively,the elimination in lung was very slow,which was 3.6 times longer than that in plasma;Area under the concentration-time curve (AUC_0-∞) were 372.05 and 94.59 μg·h/mL,respectively;Apparent distribution volume (Vd/F) were 0.41 and 5.24 L/kg,respectively,ceftiofur showed highly combined with lung.The corresponding PK parameters in infection groups were as follow:C_max were 11.81 and 5.05 μg/mL respectively;T_1/2 were 11.79 and 24.65 h,respectively;AUC_0-∞ were 162.65 and 29.73 μg·h/mL respectively;Vd/F were 0.53 and 4.65 L/kg,respectively.It showed the same characteristics as the healthy group.The results showed that ceftiofur hydrochloride injection had the PK characteristics of rapid absorption,slow elimination and high bioavailability in pigs,and there were significant differences in PK parameters between plasma and BALF.

Key words: ceftiofur hydrochloride injection; pharmacokinetic; pigs; plasma

CLC Number:

S859.7

PU Shanju, HUANG Lingli, MI Kun, SUN Da, WANG Hanyu, PAN Yuanhu, LIU Zhenli. Comparative Pharmacokinetics of Ceftiofur Hydrochloride Injection in Pigs[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(4): 1472-1481.

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Comparative Pharmacokinetics of Ceftiofur Hydrochloride Injection in Pigs

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