TET介导的DNA主动去甲基化的机制与功能研究进展

doi:10.16431/j.cnki.1671-7236.2018.05.023

Abstract

Abstract:

TET protein is a family of alpha-ketoglutarate/Fe²⁺ dependent dioxygenases that oxidize 5-methylcytosine (5mC) to produce 5-hydroxymethylcytosine (5hmC),5-formylcytosine (5fC) and 5-carboxycytosine (5caC).In recent years,TET protein play a key role in DNA demethylation,and involve in the early development of mammals.5mC was oxidized by TET protein,5fC and 5caC were oxidized by thymine DNA glycosylase (TDG),5caC was cut by TDG,and finally unmodified cytosine was obtained after base excision repair to achieve the purpose of demethylation,this pathway was widely accepted.Regulatory methods in demethylation include regulation of TET protein levels,regulation of metabolites and cofactors.And this article focuses on the role of demethylation during embryonic development.

Key words: TET proteins; DNA demethylation; regulatory mechanisms; reproductive effects

CLC Number:

LI Wen, CAO Junguo, CHEN Min, XU Baozeng. Research Progress on Mechanism and Function of TET Mediated DNA Demethylation[J]. , 2018, 45(5): 1304-1311.

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Research Progress on Mechanism and Function of TET Mediated DNA Demethylation

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