China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (9): 3500-3507.doi: 10.16431/j.cnki.1671-7236.2022.09.024
• Genetics and Breeding • Previous Articles Next Articles
WANG Yue1,2, ZHENG Yunxi3, XU Songsong2,4, XIANG Guangming2, LI Hua1, WANG Nan2, FENG Zheng1, LI Kui4, MU Yulian2
Received:
2022-05-05
Online:
2022-09-05
Published:
2022-08-24
CLC Number:
WANG Yue, ZHENG Yunxi, XU Songsong, XIANG Guangming, LI Hua, WANG Nan, FENG Zheng, LI Kui, MU Yulian. Regulation of Wip1 Gene on Animal Reproduction and Immunity[J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(9): 3500-3507.
[1] FISCELLA M, ZHANG H, FAN S, et al.Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner[J].Proceedings of The National Academy of Sciences of The United States of America, 1997, 94(12):6048-6053. [2] CHOI J, APPELLA E, DONEHOWER L A.The structure and expression of the murine wildtype p53-induced phosphatase 1(Wip1) gene[J].Genomics, 2000, 64(3):298-306. [3] LU X B, NGUYEN T A, MOON S H, et al.The type 2C phosphatase Wip1:An oncogenic regulator of tumor suppressor and DNA damage response pathways[J]. Cancer Metastasis Reviews, 2008, 27(2):123-135. [4] YODA A, XU X Z, ONISHI N, et al.Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1[J].The Journal of Biological Chemistry, 2006, 281(34):24847-24862. [5] YAMAGUCHI H, DURELL S R, CHATTERJEE D K, et al.The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases[J].Biochemistry, 2007, 46(44):12594-12603. [6] YAMAGUCHI H, MINOPOLI G, DEMIDOV O N, et al.Substrate specificity of the human protein phosphatase 2C delta Wip1[J].Biochemistry, 2005, 44(14):5285-5294. [7] JONAK K, KURPAS M, SZOLTYSEK K, et al.A novel mathematical model of ATM/p53/NF-κB pathways points to the importance of the DDR switch-off mechanisms[J].BMC Systems Biology, 2016, 10(1):75. [8] YANG Y Q, ZHENG Y H, ZHANG C T, et al.Wild-type p53-induced phosphatase 1 down-regulation promotes apoptosis by activating the DNA damage-response pathway in amyotrophic lateral sclerosis[J].Neurobiology of Disease, 2020, 134:104648. [9] LOWE J, CHA H, LEE M O, et al.Regulation of the Wip1 phosphatase and its effectson the stress response[J].Frontiers in Bioscience, 2012, 17(4):1480-1498. [10] ZHU Y H, ZHANG C W, LU L, et al.Wip1 regulates the generation of new neural cells in the adult olfactory bulb through p53-dependent cell cycle control[J].Stem Cells, 2009, 27(6):1433-1442. [11] JEONG H C, GIL N Y, LEE H S, et al.Timely degradation of Wip1 phosphatase by APC/C activator protein cdh1 is necessary for normal mitotic progression[J].Journal of Cellular Biochemistry, 2015, 116(8):1602-1612. [12] ZHANG X, PARK J E, KIM E H, et al.Wip1 controls the translocation of the chromosomal passenger complex to the central spindle for faithful mitotic exit[J].Cellular and Molecular Life Sciences, 2021, 78(6):2821-2838. [13] CHEN Z, YI W, MORITA Y, et al.Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways[J].Nature Communications, 2015, 6:6808. [14] HE W, WANG X, NI Y, et al.Wip1 regulates hematopoietic stem cell development in the mouse embryo[J].Haematologica, 2021, 106(2):580-584. [15] LI B, HU J, HE D, et al.PPM1D knockdown suppresses cell proliferation, promotes cell apoptosis, and activates p38 MAPK/p53 signaling pathway in acute myeloid leukemia[J].Technology in Cancer Research Treatment, 2020, 19:1533033820942312. [16] WANG P, YE J A, HOU C X, et al.Combination of Lentivirus-mediated silencing of PPM1D and temozolomide chemotherapy eradicates malignant glioma through cell apoptosis and cell cycle arrest[J].Oncology Reports, 2016, 36(5):2544-2552. [17] LINDQVIST A, DE BRUIJN M, MACUREK L, et al.Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression[J].The EMBO Journal, 2009, 28(20):3196-3206. [18] FERINGA F M, RAAIJMAKERS J A, HADDERS M A, et al.Persistent repair intermediates induce senescence[J].Nature Communications, 2018, 9(1):3923. [19] BURDOVA K, STORCHOVA R, PALEK M, et al.WIP1 promotes homologous recombination and modulates sensitivity to PARP inhibitors[J]. Cells, 2019, 8(10):1258. [20] HE Z Y, WANG W Y, HU W Y, et al.Gamma-H2AX upregulation caused by Wip1 deficiency increases depression-related cellular senescence in hippocampus[J].Scientific Reports, 2016, 6:34558. [21] ISSLER M V C, MOMBACH J C M.microRNA-16 feedback loop with p53 and Wip1 can regulate cell fate determination between apoptosis and senescence in DNA damage response[J].PLoS One, 2017, 12(10):e0185794. [22] SONG Y, ZHANG Z, YU Z, et al.Wip1 aggravates the cerulein-induced cell autophagy and inflammatory injury by targeting STING/TBK1/IRF3 in acute pancreatitis[J]. Inflammation, 2021, 44(3):1175-1183. [23] CHOI J, NANNENGA B, DEMIDOV O N, et al.Mice deficient for the wild-type p53-induced phosphatase gene (Wip1) exhibit defects in reproductive organs, immune function, and cell cycle control[J]. Molecular Biology of the Cell, 2002, 22(4):1094-1105. [24] 邱乙卿, 高倩, 魏迎辉, 等.小鼠Wip1基因的表达及其对受精能力的影响[J].中国畜牧兽医, 2019, 46(10):3007-3015. QIU Y Q, GAO Q, WEI Y H, et al.Expression of Wip1 gene and its effect on fertilization ability in mice[J].China Animal Husbandry & Veterinary Medicine, 2019, 46(10):3007-3015.(in Chinese) [25] FILIPPONI D, MULLER J, EMELYANOV A, et al.Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation[J].Cancer Cell, 2013, 24(4):528-541. [26] CHO S J, CHA B S, KWON O S, et al.Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development[J].Biochimica et Biophysicaacta-Molecular Basis of Disease, 2017, 1863(4):1013-1022. [27] NIU P X, WEI Y H, GAO Q, et al.Male fertility potential molecular mechanisms revealed by iTRAQ-based quantitative proteomic analysis of the epididymis from Wip1(-/-)mice[J]. Omics:A Journal of Integrative Biology, 2019, 23(1):54-66. [28] WEI Y H, GAO Q, NIU P X, et al.Integrative proteomic and phosphoproteomic profiling of testis from Wip1 phosphatase-knockout mice:Insights into mechanisms of reduced fertility[J].Molecular & Cellular Proteomics, 2019, 18(2):216-230. [29] 车晶晶, 徐奎, 张秀玲, 等.基于CRISPR/Cas9技术的Wip1基因敲除ST细胞的建立[J].畜牧兽医学报, 2021, 52(10):2814-2821. CHE J J, XU K, ZHANG X L, et al.Establishment of Wip1-knockout ST cells mediated by CRISPR/Cas9 system[J].Acta Veterinaria et Zootechnica Sinica, 2021, 52(10):2814-2821.(in Chinese) [30] WANG B Y, ZHANG M R, CHE J J, et al.Wild-type p53-induced phosphatase 1(Wip1) regulates the proliferation of swine sertoli cells through p53[J].Reproduction Fertility and Development, 2020, 32(18):1350-1356. [31] XU K, ZHANG X L, LIU Z G, et al.A transgene-free method for rapid and efficient generation of precisely edited pigs without monoclonal selection[J].Science China.Life Science, 2022, 28:1-12. [32] 李远发, 董莹金, 郑程, 等. Wip1基因在人精子中的表达及与精子浓度和活力的相关性研究[J].广西医科大学学报, 2019, 36(4):593-597. LI Y F, DONG Y J, ZHENG C, et al.Expression of Wip1 gene in human sperm and its correlation with sperm concentration and motility[J].Journal of Guangxi Medical University, 2019, 36(4):593-597.(in Chinese) [33] LEEM J, KIM J S, OH J S.WIP1 phosphatase suppresses the DNA damage response during G2/prophase arrest in mouse oocytes[J]. Reproductive Biology, 2018, 99(4):798-805. [34] LEEM J, BAI G Y, KIM J S, et al.Increased Wip1 expression with aging suppresses the capacity of oocytes to respond to and repair DNA damage[J].Frontiers in Cell and Developmental Biology, 2021, 9:810928. [35] TAN B, TONG C, YUAN Y, et al.The regulation of trophoblastic p53 homeostasis by the p38-Wip1 feedback loop is disturbed in placentas from pregnancies complicated by preeclampsia[J].Cellular Physiology and Biochemistry, 2019, 52(2):315-335. [36] PARK D S, YOON G H, KIM E Y, et al.Wip1 regulates Smad4 phosphorylation and inhibits TGF-beta signaling[J].EMBO Reports, 2020, 21(5):e48693. [37] ZHOU S, XI Y, CHEN Y, et al.The inhibition of WIP1 phosphatase accelerates the depletion of primordial follicles[J].Reproductive Biomedicine Online, 2021, 43(2):161-171. [38] SCHITO M L, DEMIDOV O N, SAITO S, et al.Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation[J].The Journal of Immunology, 2006, 176(8):4818-4825. [39] SUN L, LI H, LUO H, et al.Phosphatase Wip1 is essential for the maturation and homeostasis of medullary thymic epithelial cells in mice[J]. The Journal of Immunology, 2013, 191(6):3210-3220. [40] MARTINIKOVA A S, BUROCZIOVA M, STOYANOV M, et al.Truncated PPM1D prevents apoptosis in the murine thymus and promotes ionizing radiation-induced lymphoma[J].Cells, 2020, 9(9):2068. [41] EREN M K, KARTAL N B, PILEVNELI H.Oncogenic Wip1 phosphatase attenuates the DNA damage response and sensitizes p53 mutant Jurkat cells to apoptosis[J]. Oncology Letters, 2021, 21(6):479. [42] YI W, HU X, CHEN Z, et al.Phosphatase Wip1 controls antigen-independent B cell development in a p53-dependent manner[J].Blood, 2015, 126(5):620-628. [43] LIU G, HU X, SUN B, et al.Phosphatase Wip1 negatively regulates neutrophil development through p38 MAPK-STAT1[J].Blood, 2013, 121(3):519-529. [44] SUN B, HU X, LIU G, et al.Phosphatase Wip1 negatively regulates neutrophil migration and inflammation[J]. The Journal of Immunology, 2014, 192(3):1184-1195. [45] SHEN X F, ZHAO Y, CAO K, et al.Wip1 deficiency promotes neutrophil recruitment to the infection site and improves sepsis outcome[J].Frontiers in Immunology, 2017, 8:1023. [46] ZHANG Q, ZHANG C P, CHANG F Z, et al.Wip1 inhibits intestinal inflammation in inflammatory bowel disease[J].Cellular Immunology, 2016, 310:63-70. [47] UYANIK B, GOLOUDINA A R, AKBARALI A, et al.Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses[J].Nature Communications, 2021, 12(1):3622. [48] TANG Y, PAN B, ZHOU X, et al.Wip1-dependent modulation of macrophage migration and phagocytosis[J].Redox Biology, 2017, 13:665-673. [49] 周慧慧.Wip1增强巨噬细胞干细胞样特性促进肿瘤进展的机制研究[D].南京:南京中医药大学, 2021. ZHOU H H.Wip1 enhances stem cell-like properties of macrophages and promotes tumor propression[D].Nanjing:Nanjing University of Chinese Medicine, 2021.(in Chinese) [50] PECHACKOVA S, BURDOVA K, BENADA J, et al.Inhibition of Wip1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3[J].Oncotarget, 2016, 7(12):14458-14475. [51] LIU Y, XU J, CHOI H H, et al.Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer[J].Nature Communications, 2018, 9(1):4718. [52] MAHDAVI M, NASSIRI M, KOOSHYAR M M, et al.Hereditary breast cancer:Genetic penetrance and current status with BRCA[J].Journal of Cellular Physiology, 2019, 234(5):5741-5750. [53] WANG J, WANG G, CHENG D, et al.Her2 promotes early dissemination of breast cancer by suppressing the p38-MK2-Hsp27 pathway that is targetable by Wip1 inhibition[J].Oncogene, 2020, 39(40):6313-6326. [54] PENG T S, HE Y H, NIE T, et al.PPM1D is a prognostic marker and therapeutic target in colorectal cancer[J].Experimental and Therapeutic Medicine, 2014, 8(2):430-434. [55] BAI F, ZHOU H, FU Z, et al.NF-kappaB-induced Wip1 expression promotes colorectal cancer cell proliferation through mTOR signaling[J].Biomedicine & Pharmacotherapy, 2018, 99:402-410. [56] WANG P, ZHAO Y, LIU K, et al.Wip1 cooperates with KPNA2 to modulate the cell proliferation and migration of colorectal cancer via a p53-dependent manner[J].Journal of Cellular Biochemistry, 2019, 120(9):15709-15718. [57] BUROCZIOVA M, BURDOVA K, MARTINIKOVA A S, et al.Truncated PPM1D impairs stem cell response to genotoxic stress and promotes growth of APC-deficient tumors in the mouse colon[J]. Cell Death & Disease, 2019, 10(11):818. [58] AKAMANDISA M P, NIE K, NAHTA R, et al.Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma[J]. Neuro-Oncology, 2019, 21(6):786-799. [59] WANG Z, XU C, DIPLAS B H, et al.Targeting mutant PPM1D sensitizes diffuse intrinsic pontine glioma cells to the PARP inhibitor olaparib[J].Molecular Cancer Research, 2020, 18(7):968-980. [60] KHADKA P, REITMAN Z J, LU S, et al.PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation[J].Nature Communications, 2022, 13(1):604. [61] KAHN J D, MILLER P G, SILVER A J, et al.PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells[J]. Blood, 2018, 132(11):1095-1105. [62] WU B, GUO B M, KANG J, et al.PPM1D exerts its oncogenic properties in human pancreatic cancer through multiple mechanisms[J]. Apoptosis, 2016, 21(3):365-378. [63] FENG Y, LIU F, DU Z, et al.Wip1 regulates SKOV3 cell apoptosis through the p38 MAPK signaling pathway[J]. Molecular Medicine Reports, 2017, 15(6):3651-3657. [64] XIA Z S, WU D, ZHONG W, et al.Wip1 gene silencing enhances the chemosensitivity of human colon cancer cells[J]. Oncology Letters, 2017, 14(2):1875-1883. |
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