NLRP7基因在母源印记中的研究进展

doi:10.16431/j.cnki.1671-7236.2018.04.021

Abstract

Abstract:

Nucleotide binding oligomerization domain-like receptors (NLRs) family is similar to Tol-like receptors (TLRs) family,which is well conserved,exists not only in plants but also in animals,and plays important roles in the innate immune system.NLRs family comprises many subfamilies,in which NACHT,LRR and PYD domains-containing protein 7 (NLRP7),a member of NLRP subfamily, which is expressed in a variety of immune cells and immune organs,and participates in cell growth,proliferation,differentiation,apoptosis and immune response(inflammation).NLRP7 was not only expressed in the immune system but also expressed in the mammalian testis and ovary of the reproductive system as well as early embryos,and NLRP7 mutations usually cause the human family recurrent hydatidiform mole disease,resulting in pregnancy failure.Recent studies have found that NLRP7 is a maternal imprinted gene,and the abnormal imprinting status of NLRP7 is closely related to the abnormal embryonic development.Although the hydatidiform mole disease has not been found in large animals such as pigs,cattle and sheep,many unexplained abortion,stillbirth and so on may be related to the mutation of NLRP7.NLRP7 has degraded in mice and other rodents during the evolution process,so the current studies of NLRP7 mainly focus on the primates.This paper reviews the latest research progress about NLRP7 in order to provide reference for the exploration of mammals reproductive disorders and other diseases.

Key words: maternal imprinted gene; NLRP7 gene; reproduction

CLC Number:

LI Guangdong, CUI Wei, TIAN Xiuzhi, LV Dongying, JI Pengyun, LIU Guoshi. Research Progress on NLRP7 Gene in Maternal Imprinting[J]. , 2018, 45(4): 1002-1008.

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Research Progress on NLRP7 Gene in Maternal Imprinting

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