家畜多脊椎性状研究进展

doi:10.16431/j.cnki.1671-7236.2017.08.024

Abstract

Abstract:

Multi-vertebra trait means increase of the vertebral number in animal, which is positive for livestock. Increased thoracic-lumbar vertebral number will result in improvement of carcass traits, especially carcass length, as well as economic value. Meanwhile, relatively high heritability of multi-vertebra trait is evaluated, providing genetic basis for selecting and breeding of multi-vertebra livestock. As such, individuals with multi-vertebra trait will increase production of domestic animals ultimately. Thus, study on multi-vertebra trait provides theoretical basis for breeding of meat livestock with multi-vertebra. Hitherto, multi-vertebra trait has been found in swine, sheep and bovine. Much information has been revealed in studies on multi-vertebra trait in swine; While that is limited in sheep and bovine. This review summarized variations of vertebral number, effects of multi-vertebra trait on the production traits, and genes or mutations responsible for multi-vertebra trait of livestock animal. Further, the research gap and future direction were analyzed as well.

Key words: livestock; multi-vertebra; production traits; regulatory genes

CLC Number:

S813.25

HUANG Jie-ping, ZHANG Ming-ming, MA Yun, HAO Rui-jie, LEI Chu-zhao. Research Progress on Multi-vertebral Trait in Livestock[J]. , 2017, 44(8): 2386-2391.

References

[1] 马仲华. 家畜解剖学及组织胚胎学[M]. 第3版. 北京:中国农业出版社, 2014.
[2] Borchers N, Reinsch N, Kalm E. The number of ribs and vertebrae in a Piétrain cross:Variation, heritability and effects on performance traits[J]. J Anim Breed Genet, 2004, 121(6):392-403.
[3] King J W B, Roberts R C. Carcass length in the bacon pig:Its association with vertebrae numbers and prediction from radiographs of the young pig[J]. Anim Prod, 1960, 2(1):59-65.
[4] Yang J, Huang L, Yang M, et al. Possible introgression of the VRTN mutation increasing vertebral number, carcass length and teat number from Chinese pigs into European pigs[J]. Sci Rep, 2016, 6:19240.
[5] Getty R. The Anatomy of the Domestic Animals[M]. W.B. Saundels Company, 1975.
[6] May N D. The Anatomy of the Sheep:A Dissection Manual[M]. University of Queensland Press, 1970.
[7] 张立岭, 罗旭光, 斯琴毕力格, 等. 多脊椎蒙古羊的胸腰椎长度及其产肉性能分析[J]. 内蒙古学院学报, 1998, 19(3):1-5.
[8] 张立岭, 斯琴毕力格. 蒙古羊多脊椎基因的群体遗传学研究[J]. 遗传,1997, 19(增刊):67-69.
[9] 韩立霞. 河北小尾寒羊多脊柱调控基因Btg2和NR6A1的多态性分析[D].保定:河北农业大学, 2009.
[10] 韩浩园, 王绍强, 黄洁萍, 等. 秦川牛多脊椎性状调查[J]. 中国牛业科学, 2013, 39(6):78-79.
[11] 杨建梅, 文勇立, 冯正平, 等. 金川牦牛胸腰椎组型变异及其与产肉性能的相关分析[J]. 家畜生态学报, 2015, 36(9):26-30.
[12] Hirose K, Mikawa S, Okumura N, et al. Association of swine vertnin (VRTN) gene with production traits in Duroc pigs improved using a closed nucleus breeding system[J]. Anim Sci J Nihon Chikusan Gakkaihō, 2013, 84(3):213-221.
[13] Nakano H, Sato S, Uemoto Y, et al. Effect of VRTN gene polymorphisms on Duroc pig production and carcass traits, and their genetic relationships[J]. Anim Sci J Nihon Chikusan Gakkaihō, 2015, 86(2):125-131.
[14] Burgos C, Latorre P, Altarriba J, et al. Allelic frequencies of NR6A1 and VRTN, two genes that affect vertebrae number in diverse pig breeds:A study of the effects of the VRTN insertion on phenotypic traits of a Duroc×Landrace-Large White cross[J]. Meat Sci, 2015, 100:150-155.
[15] Rijli F M, Matyas R, Pellegrini M, et al. Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice[J]. Proc Natl Acad Sci USA, 1995, 92(18):8185-8189.
[16] Garcia-Fernàndez J. The genesis and evolution of homeobox gene clusters[J]. Nat Rev Genet, 2005, 6(12):881-892.
[17] Wellik D M. Hox patterning of the vertebrate axial skeleton[J]. Dev Dyn off Publ Am Assoc Ana, 2007, 236(9):2454-2463.
[18] Gomez C, Ozbudak E M, Wunderlich J, et al. Control of segment number in vertebrate embryos[J]. Nature, 2008, 454(7202):335-339.
[19] McPherron A C, Lawler A M, Lee S J. Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11[J]. Nat Genet, 1999, 22(3):260-264.
[20] McPherron A C, Huynh T V, Lee S J. Redundancy of myostatin and growth/differentiation factor 11 function[J]. BMC Dev Biol, 2009, 9(1):1-9.
[21] Li Z, Kawasumi M, Zhao B, et al. Transgenic over-expression of growth differentiation factor 11 propeptide in skeleton results in transformation of the seventh cervical vertebra into a thoracic vertebra[J]. Mol Reprod Dev, 2010, 77(11):990-997.
[22] Oh S P, Li E. The signaling pathway mediated by the type ⅡB activin receptor controls axial patterning and lateral asymmetry in the mouse[J]. Genes Dev, 1997, 11(14):1812-1826.
[23] Oh S P, Yeo C Y, Lee Y, et al. Activin type ⅡA and ⅡB receptors mediate GDF11 signaling in axial vertebral patterning[J]. Genes Dev, 2002, 16(21):2749-2754.
[24] Prévôt D, Voeltzel T, Birot A M, et al. The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation[J]. J Biol Chem, 2000, 275(1):147-153.
[25] Park S, Lee Y J, Lee H J, et al. B-Cell translocation gene 2(Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/Smad signaling[J]. Mol Cell Biol, 2004, 24(23):10256-10262.
[26] Mikawa S, Morozumi T, Shimanuki S I, et al. Fine mapping of a swine quantitative trait locus for number of vertebrae and analysis of an orphan nuclear receptor, germ cell nuclear factor (NR6A1)[J]. Genome Res, 2007, 17(5):586-593.
[27] Mikawa S, Sato S, Nii M, et al. Identification of a second gene associated with variation in vertebral number in domestic pigs[J]. BMC Genet, 2011, 12(1):1-13.
[28] Juan A H, Lei H, Bhargava P, et al. Multiple roles of hoxc8 in skeletal development[J]. Ann N Y Acad Sci, 2006, 1068(1):87.
[29] Kimura T, Shinya M, Naruse K. Genetic analysis of vertebral regionalization and number in medaka (Oryzias latipes) inbred lines[J]. G3 Bethesda Md, 2012, 2(11):1317-1323.
[30] Wong S F L, Agarwal V, Mansfield J H, et al. Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs[J]. Proc Natl Acad Sci USA, 2015, 112(35):E48840-E4893.
[31] Wada Y, Akita T, Awata T, et al. Quantitative trait loci (QTL) analysis in a Meishan×Göttingen cross population[J]. Anim Genet, 2000, 31(6):376-384.
[32] Rohrer G A, Keele J W. Identification of quantitative trait loci affecting carcass composition in swine:Ⅱ. Muscling and wholesale product yield traits[J]. J Anim Sci, 1998, 76(9):2255-2262.
[33] Mikawa S, Hayashi T, Nii M, et al. Two quantitative trait loci on chromosomes 1 and 7 affecting the number of vertebrae[J].J Anim Sci,2005, 83(10), 2247-2254.
[34] Zhang L, Liu X, Liang J, et al. Genome-wide association study for number of vertebrae in an F2 Large White×Minzhu population of pigs[J]. Bio Rxiv, 2015:16956.
[35] Sato S, Uemoto Y, Kikuchi T, et al. SNP-and haplotype-based genome-wide association studies for growth, carcass, and meat quality traits in a Duroc multigenerational population[J]. BMC Genet, 2016, 17(1):1-17.
[36] Chung A C, Katz D, Pereira F A, et al. Loss of orphan receptor germ cell nuclear factor function results in ectopic development of the tail bud and a novel posterior truncation[J]. Mol Cell Biol, 2001, 21(2):663-677.
[37] Chung A C K, Xu X, Niederreither K A, et al. Loss of orphan nuclear receptor GCNF function disrupts forebrain development and the establishment of the isthmic organizer[J].Dev Biol,2006, 293(1):13-24.
[38] Fan Y, Xing Y, Zhang Z, et al. A further look at porcine chromosome 7 reveals VRTN variants associated with vertebral number in Chinese and Western pigs[J]. PLoS One, 2013, 8(4):e62534.
[39] Ren D R, Ren J, Ruan G F, et al. Mapping and fine mapping of quantitative trait loci for the number of vertebrae in a White Duroc×Chinese Erhualian intercross resource population[J]. Anim Genet, 2012, 43(5):545-551.
[40] Zhang L C, Yue J W, Pu L, et al. Genome-wide study refines the quantitative trait locus for number of ribs in a Large White×Minzhu intercross pig population and reveals a new candidate gene[J]. Mol Genet Genomics, 2016,291(5):1885-1890.
[41] Rohrer G A, Nonneman D J, Wiedmann R T, et al. A study of vertebra number in pigs confirms the association of vertnin and reveals additional QTL[J]. BMC Genet, 2015, 16:129.
[42] 张立岭. 乌珠穆沁羊脊椎数变异的群体遗传特性研究[J]. 内蒙古畜牧科学, 1996, 4:1-3.
[43] 张立岭. 乌珠穆沁羊Homeobox基因突变与椎骨数变异的研究[J]. 内蒙古农牧学院学报, 1996, 17(3):29-33.
[44] 陈琦, 赵静, 张立岭, 等. 多脊椎蒙古羊Hoxc8 exon-1和exon-2的序列分析[J]. 热带生物学报, 2011, 2(2):157-163.
[45] 陈琦, 赵静, 张立岭, 等. 多脊椎蒙古羊Hoxc8 exon-1甲基化分析[J]. 中国畜牧杂志, 2009, 45(23):10-14.
[46] 刘建明, 孙少华, 韩立霞, 等. ActR Ⅱ B 基因单核苷酸多态性与小尾寒羊多脊椎变异的关联研究[J]. 畜牧兽医学报, 2010, 41(8):951-954.
[47] 何小龙, 李蓓, 付绍印, 等. 乌珠穆沁羊生长分化因子11基因外显子1序列CpG位点的甲基化模式分析[J]. 中国畜牧兽医, 2016, 43(2):333-339.

Research Progress on Multi-vertebral Trait in Livestock

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LI Jie, CHEN Chuwen, ZHAO Ruipeng, LIU Yuan, LI Zhixiong. Research Progress on Long Non-coding RNA of Muscle Development in Livestock and Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(6): 2427-2438.
[2]	SUN Yanyong, MA Fengying, GUO Lili, LIU Zaixia, LIU Bin, ZHANG Wenguang, LIU Yongbin. Advances on the Application of Animal Blood Transcriptome [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 460-468.
[3]	GAO Yang, DU Xin, MA Xue, ZHANG Yingmei, HUO Changqing. Regulation of Resveratrol on Nrf2,NF-κB and Wnt Signaling Pathways and Its Application in Animals Production [J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 512-518.
[4]	XU Jing, YANG Guang, JIANG Meiqi, DING Xiangbin, GUO Yiwen, HU Debao, LI Xin, GUO Hong, ZHANG Linlin. Research Advances on CRISPR/Cas9 Technology in Livestock and Poultry Breeding [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(4): 1374-1383.
[5]	QIAO Chunyu, LIU Jiahe, ZHANG Boxi, HE Yuxi, ZHENG Yuwei, LYU Hongming. Research Progress on Pathogenic Mechanism and Control of Aflatoxin B₁ [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(2): 765-775.
[6]	LIANG Shasha, PANG Chunying, DENG Tingxian, LU Xingrong, DUAN Anqin, MA Xiaoya, FANG Yanyan, LIANG Xianwei. Polymorphism of MFSD2A Gene and Its Association with Milk Production Traits in Buffalo [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(10): 3856-3865.
[7]	YANG Xinbo, ZHANG Xiaoxuan, CAI Yanan, NI Hongbo, ZHAO Quan, MA He. Progress on Microbial Fermented Traditional Chinese Medicine and Its Application in Breeding Industry [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 169-178.
[8]	SHI Yuanjun, MI Siyuan, YU Ying. Research Progress on m⁶A Epigenetic Modification and Its Regulation Mechanism [J]. China Animal Husbandry and Veterinary Medicine, 2022, 49(1): 197-207.
[9]	CHEN Jifa. Nutritional Characteristic of Tenebrio molitor and Its Application in Livestock and Poultry Diets [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2424-2430.
[10]	JING Zhenzhu, QIN Panpan, CHEN Bingjie, HOU Dan, WEI Chengjie, LI Tong, HAN Ruili, LIU Xiaojun, TIAN Yadong, KANG Xiangtao, LI Zhuanjian. Research Progress of Copy Number Variation in Livestock and Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(7): 2512-2522.
[11]	HE Weizhao, ZHANG Huiyan, WANG Hao, ZHAO Qingyu, TANG Chaohua, ZHANG Junmin. Extraction Methods of Yolk Antibody and Its Application in Prevention and Treatment of Bacterial Intestinal Diseases in Livestock and Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(2): 640-649.
[12]	XU Xi, YANG Sha, HAO Haisheng, DU Weihua, PANG Yunwei, ZHAO Shanjiang, ZOU Huiying, ZHU Huabin, LI Shujing, YU Wenli, ZHAO Xueming. Research Progress on Application of Single Base Editing Technology [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(12): 4403-4411.
[13]	SHANG Fangzheng, HAN Wenjing, WU Zhihong, HAI Erhan, MA Rong, ZHANG Yanjun, LI Jinquan. Research Advance on Application of Non-coding RNA in Livestock and Poultry [J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 235-247.
[14]	LU Qicheng, WU Yanyan, ZHANG Wenju. Biological Function,Mechanism of Action and Application of Saccharomyces boulardii [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(8): 2472-2480.
[15]	FAN Lixia, YUAN Xuexia, LI Yuanyang, WU Yuanjuan, ZHAO Shancang, ZHANG Bingchun, WANG Wenbo. LAMP Detection and Drug Resistance Analysis to Staphylococcus aureus and Escherichia coli in Livestock and Poultry Manure [J]. China Animal Husbandry and Veterinary Medicine, 2020, 47(7): 2325-2335.