白藜芦醇对Nrf2、NF-κB和Wnt信号通路的调控及其在动物生产中的应用

doi:10.16431/j.cnki.1671-7236.2023.02.009

Abstract

Abstract: Resveratrol (RES) is a natural non-flavonoid polyphenol compound that exists widely in various plant tissues,such as grapes,tab wraps,and peanuts,it is an important substance that plants resist the invasion of pathogenic microorganisms and maintain their stability,so it is also called plant antitoxin.RES has good antioxidant,anti-inflammatory,and antibacterial characteristics,and plays an important role in improving animal resistance,improving immune capacity,and maintaining intestinal health.RES can promote the expression of nuclear factor E2-related factor 2 (Nrf2) in livestock and poultry by regulating Nrf2-Kelch-like oxide propylene-1 (keap 1),and improve antioxidant factor expression and antioxidizes activity,relieves oxidation stress,reduces the level of inflammatory factor expression and the inflammatory response by regulating nuclear factor-κB (NF-κB) signaling pathway.In terms of animal intestinal health,RES can promote the proliferation and differentiation of intestinal epithelial cells by regulating the Wnt/β-serial protein (Wnt/β-catenin) signaling pathway,improving intestinal mucosal barrier integrity,promoting intestinal microbial planting,and then improving the intestinal flora structure.As a natural supplementation,RES can improve the growth performance and growth potential of animals,and improve the quality of livestock and poultry products.At the same time,RES can enhance the immune function of animals,improve their ability to resist pathogens,and reduce the incidence of disease.At present,RES has been widely used in the production of livestock and poultry,but it still needs to be further understood by its specific mechanism.The authors introduced the specific mechanism of RES regulating Nrf2-Keap1,NF-κB and Wnt/β-catenin signaling pathways,and its application prospects in livestock and poultry production,in order to provide a theoretical basis for the in-depth application of RES in animal production.

Key words: resveratrol; Nrf2-Keap1; NF-κB; Wnt/β-catenin; livestock and poultry production

CLC Number:

S816.7

GAO Yang, DU Xin, MA Xue, ZHANG Yingmei, HUO Changqing. Regulation of Resveratrol on Nrf2,NF-κB and Wnt Signaling Pathways and Its Application in Animals Production[J]. China Animal Husbandry and Veterinary Medicine, 2023, 50(2): 512-518.

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Regulation of Resveratrol on Nrf2,NF-κB and Wnt Signaling Pathways and Its Application in Animals Production

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