上皮间质转化促乳腺癌机制及药物干预治疗研究进展

doi:10.16431/j.cnki.1671-7236.2021.01.013

Abstract

Abstract: Breast cancer is a common disease in dogs,cats and other companion animals and humans.As a malignant tumor and the main cause of death of humans and animals,the disease burden of breast cancer is still gradually increasing,and the prevention and treatment situation of breast cancer is becoming more and more serious.Epithelial-mesenchymal transition (EMT) plays an important role in biological process in the development of breast cancer,which can also promote the invasion,metastasis and drug resistance of malignant tumors.Therefore,it is getting more and more attention in cancer research,and targeting EMT is an important research direction and hotspot in the treatment of breast cancer.In this paper,the changes of cell morphology and function and markers,the classification of EMT and the relationship between EMT and breast cancer were discussed respectively.The EMT-related TGF-β/Smad,NF-κB and Wnt signaling pathways were analyzed in detail.And then advances in the treatment of breast cancer,including the development of inhibitors of TGF-β/Smad pathway,the prospect of treatment with related drugs,genes and cytokines,and the experimental results of NF-κB pathway and Wnt pathway inhibitors,were discussed in detail.Finally,the development and trend of the treatment of breast cancer were prospected.Deeply understanding the biological process of breast cancer EMT regulated by signaling pathway,making clear its occurrence development mechanism,finding key targets and developing targeted drugs,will bring the dawn for the precise treatment of breast cancer.

Key words: breast cancer; epithelial-mesenchymal transition; targeted therapy; TGF-β/Smad; NF-κB; Wnt

CLC Number:

S853.74

LIN Changjie, LI Ting, TANG Xin, CHEN Yingyu, GUO Aizhen, HU Changmin. Advances in the Mechanism of Epithelial-mesenchymal Transition for Breast Cancer Promotion and Drug Intervention[J]. China Animal Husbandry and Veterinary Medicine, 2021, 48(1): 117-123.

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Advances in the Mechanism of Epithelial-mesenchymal Transition for Breast Cancer Promotion and Drug Intervention

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