家兔IGF1基因多态性与生长性状的关联分析

doi:10.16431/j.cnki.1671-7236.2017.08.023

Abstract

Abstract:

This study was aimed to analyze the association of insulin-like growth factor 1 (IGF1) gene polymorphisms with growth traits in rabbit. The technology of DNA pooling, PCR-SSCP and direct sequencing were used to detect the SNP of IGF1 gene. The results showed that T365C was detected in IGF1 gene exon 3 of rabbit. The SNP (C/T) was devised into three genotypes:TT, TC and CC. The relationships between genotypes and growth traits revealed that the birth weight and the weight at 28 days of age in New Zealand rabbit of TT genotype of T365C locus were significantly higher than TC and CC genotypes (P<0.05), the birth weight, the weight at 90 days of age and average daily gain form birth to 90 days of age in Belgian rabbit of TT genotype of T365C locus were significantly higher than TC and CC genotypes (P<0.05), there were no significant difference of the growth traits in other rabbit breeds (P>0.05).The consequence indicated that IGF1 gene was primarily deduced to be a potential major gene or linked to major gene effecting the growth traits of rabbit, and this SNP (T365C) might be a candidate molecular genetic markers to improve the growth traits of rabbit.

Key words: rabbit; IGF1 gene; growth traits

CLC Number:

S813.3

XIAO Chao-neng, WENG Ji-mei, LI Wei, JIANG Zhao-hua, LIN Jia-dong, LIU Ruo-yu, LIN Hong-lin, ZU Pan-yu, ZHANG Fu-ping. Association Analysis Between Polymorphism of IGF1 Gene and Growth Traits in Rabbit[J]. , 2017, 44(8): 2378-2385.

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Association Analysis Between Polymorphism of IGF1 Gene and Growth Traits in Rabbit

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