China Animal Husbandry and Veterinary Medicine ›› 2022, Vol. 49 ›› Issue (1): 197-207.doi: 10.16431/j.cnki.1671-7236.2022.01.021

• Genetics and Breeding • Previous Articles     Next Articles

Research Progress on m6A Epigenetic Modification and Its Regulation Mechanism

SHI Yuanjun, MI Siyuan, YU Ying   

  1. College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
  • Received:2021-09-06 Online:2022-01-05 Published:2021-12-29

Abstract: N6-methyladenosine (m6A) is the most prevalent epigenetic modification of eukaryotic RNA, it is highly conserved among eukaryotes and plays important roles in gene expression and cell fate determination. Meanwhile, it has great influence on mRNA processing, including alternative splicing, localization, translation efficiency and stability. The existing m6A modification detection technology can accurately and efficiently detect the m6A modification abundance in biological samples, quickly and easily carry out high-throughput sequencing of m6A modification, and detect the position of m6A modification on RNA at single base resolution. Although there are a few reports on m6A-related proteins regulating animal complex economic traits, the mechanisms are still unclear. A lots of studies on humans and model organisms showed that m6A-related proteins play the vital roles in lots of biological process, such as growth and development, reproduction, heat stress, inflammation and cancer, and these ideas and discoveries can provide a great reference for exploring the effect of m6A on domestic animals' complex economic traits. The author mainly expounds m6A methylation modification related proteins (writers, erasers and readers), m6A detection technology, the regulation mechanism of m6A on complex traits of mammals, and the interaction mechanism between m6A and other eoigenetic modifications, so as to provide new insights for the application of m6A in livestock and poultry genetic breeding.

Key words: N6-methyladenosine(m6A); livestock and poultry; economic traits; molecular regulation mechanism

CLC Number: