线粒体未折叠蛋白反应的研究进展

doi:10.16431/j.cnki.1671-7236.2015.07.024

Abstract

Abstract: Mitochondria,as one of important intracellular organelles,regulates many intracellular signaling pathways,but environmental stress can cause accumulation of large amounts of misfolded or unfolded proteins,resulting in mitochondrial dysfunction.Current studies have revealed that a variety forms of signaling pathway from mitochondria to nucleus which can alleviate mitochondrial stress reaction and maintain mitochondrial homeostasis.In this paper,we will lay emphasis on that the molecular mechanisms of retrograde reactions in Saccharomyces cerevisiae,mitochondrial unfolded protein response in mammalian cells and C.elegans,and the interaction between mitochondrial unfolded protein response and mitophagy,innate immunity.

Key words: mitochondria; retrograde response; unfolded protein response; mitophagy

CLC Number:

Q244

LI Shuai-feng, HU Lin, WANG Jia-xing, ZHANG Shu-jun. Research Progress on Mitochondrial Unfolded Protein Response[J]. , 2015, 42(7): 1787-1792.

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Research Progress on Mitochondrial Unfolded Protein Response

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