›› 2013, Vol. 40 ›› Issue (6): 139-142.

• 生理生化 • 上一篇    下一篇

中国实验用小型猪血液指标正常参考值分析

冯媛媛1,2, 白雪源1, 贺津3, 叶建华3, 陈香美1   

  1. 1. 解放军总医院肾病科, 肾脏疾病国家重点实验室, 北京 100853;
    2. 南开大学医学院, 天津 300192;
    3. 中国农业大学农业生物技术国家重点实验室, 北京 100193
  • 收稿日期:2012-11-29 出版日期:2013-06-20 发布日期:2013-06-20
  • 通讯作者: 白雪源 E-mail:xueyuan_bai@yahoo.com.cn
  • 作者简介:冯媛媛(1987-),女,陕西人,硕士生,研究方向:糖尿病。
  • 基金资助:
    国家重点基础研究计划(973计划)项目(2011CBA01003);国家重大科学研究计划项目(2011CB964904)。

Analysis of Blood Parameters in Chinese Experimental Mini-pigs

FENG Yuan-yuan1,2, BAI Xue-yuan1, HE Jin3, YE Jian-hua3, CHEN Xiang-mei1   

  1. 1. State Key Laboratory of Kidney Diseases, Department of Nephrology, Chinese PLA General Hospital, Beijing 100853, China;
    2. Medical School, Nankai University, Tianjin 300192, China;
    3. State Key Laboratory of Agricultural Biotechnology, China Agricultural University, Beijing 100193, China
  • Received:2012-11-29 Online:2013-06-20 Published:2013-06-20

摘要: 本试验旨在建立中国农业大学教授专家团队培育的小型猪(命名为"中国实验用小型猪")血液生理和生化指标的正常参考值范围,为小型猪作为人类疾病模型提供参考依据。用全自动化生化仪测定1、3、6和12月龄中国实验用小型猪血液的9项生理指标和22项生化指标,对同一月龄不同性别的血液测定值进行单因素独立样本t检验。试验结果显示,中国实验用小型猪绝大多数血液生理生化指标同一月龄不同性别间差异不显著(P>0.05),仅红细胞体积分布宽度和肌酐等指标存在显著差异(P<0.05)。中国实验用小型猪血液指标与巴马小型猪、贵州小型猪和五指山小型猪相比,大多数血液测定值接近。试验结果表明,中国实验用小型血液生理生化指标稳定,与人类正常参考值相比,小型猪9项血液生理指标中有4项和人类相接近,22项血液生化指标中有15项和人类相接近。

关键词: 中国实验用小型猪; 血液生理指标; 血液生化指标

Abstract: This assay was aimed to determine the blood physiological and biochemical parameters in the mini-pigs bred by China Agricultural University which was named Chinese experimental mini-pigs,so as to provide the basis for mini-pigs as human disease models.Nine physiological blood paramaters and twenty two biochemical blood paramaters in Chinese experimental mini-pigs aged 1,3,6 and 12 months were measured using the automatic biochemical analyzer.The blood parameters between males and females in the same month were compared. The results showed among the blood physiological and biochemical parameters,only RDW and CREA showed significant difference between male and female pigs in the same month in Chinese experimental mini-pigs (P<0.05). Some blood parameters in Chinese experimental mini-pigs were similar to those in Bama mini-pig, Guizhou mini-pig and Wuzhishan mini-pig.The blood physiological and biochemical parameters in Chinese experimental mini-pig were very stable.Compared with human beings,four of nine physiological blood paramaters and fifteen of twenty-two biochemical blood paramaters in Chinese experimental mini-pigs were similar.

Key words: Chinese experimental mini-pig; blood physiological parameters; blood biochemical parameters

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