乳酸杆菌在调节肠道屏障功能中的作用

中国畜牧兽医

乳酸杆菌在调节肠道屏障功能中的作用

朱翠^1,2, 师子彪^1,3, 蒋宗勇¹, 王丽¹

1. 广东省农业科学院畜牧研究所,畜禽育种国家重点实验室,农业部华南动物营养与饲料重点实验室, 广东省动物育种与营养公共实验室,广东广州 510640;
2. 华南农业大学动物科学学院,广东广州 510642;
3. 中山大学生命科学学院,广东广州 510006

收稿日期:2012-02-07 出版日期:2012-09-20 发布日期:2012-09-18
通讯作者: 蒋宗勇(1963—),男,重庆人,研究员,主要从事单胃动物营养研究工作。E-mail:jiangz38@gmail.com E-mail:jiangz38@gmail.com
作者简介:朱翠(1985—),女,广东人,博士生,研究方向:动物营养与饲料科学。
基金资助:
国际科技合作项目(2009DFA31570);国家现代农业产业技术体系建设专项(CARS-36);省部产学研结合项目(2009B090200067);广东省农业科学院院长基金项目(1313041166383)。

Roles of Lactobacillus in Regulating Intestinal Barrier Functions

ZHU Cui^1,2, SHI Zi-biao^1,3, JIANG Zong-yong¹, WANG Li¹

1. Guangdong Public Laboratory of Animal Breeding and Nutrition, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture, P.R.China, State Key Laboratory of Livestock and Poultry Breeding, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou 510640,China;
2. College of Animal Science, South China Agricultural University, Guangzhou 510642,China;
3. School of Life Sciences, Sun Yat-Sen University, Guangzhou 510006,China

Received:2012-02-07 Online:2012-09-20 Published:2012-09-18

摘要/Abstract

摘要： 乳酸杆菌不仅是动物肠道内存在的正常微生物,也是益生菌的重要组成部分。肠道屏障主要是由肠道黏膜免疫系统组成的免疫屏障、肠黏液层和肠上皮细胞层组成的肠黏膜物理屏障及肠道微生物构成的生物屏障构成。作者综述了近年来国内外有关乳酸杆菌制剂对肠道屏障功能调控作用的研究进展。

关键词: 乳酸杆菌; 肠道屏障; 通透性; 紧密连接

Abstract: Lactobacilli is not only the normal commensal bacteria in the intestine of animals, but also makes up an important portion of probiotic. Intestinal barriers mainly include the immune barrier composed with intestinal mucosal immunity system, intestinal mucosal barrier composed with intestinal mucin layer and epithelial cell layer, as well as the biological barrier composed with gut microflora. This review mainly summarizes the regulative effects of Lactobacillus on intestinal barrier functions.

Key words: Lactobacillus; intestinal barrier function; permeability; tight junction

中图分类号:

Q819

朱翠, 师子彪, 蒋宗勇, 王丽. 乳酸杆菌在调节肠道屏障功能中的作用[J]. 中国畜牧兽医.

ZHU Cui, SHI Zi-biao, JIANG Zong-yong, WANG Li. Roles of Lactobacillus in Regulating Intestinal Barrier Functions[J]. China Animal Husbandry & Veterinary Medicine.

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