›› 2011, Vol. 38 ›› Issue (5): 163-166.

• 疾病防治 • 上一篇    下一篇

白细胞介素-16的研究进展

吴松明1, 朱兴全1,2, 袁子国1   

  1. 1. 华南农业大学兽医学院,广东广州 510642;2. 中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室,甘肃兰州 730046
  • 收稿日期:2010-11-21 修回日期:1900-01-01 出版日期:2011-05-20 发布日期:2011-05-20
  • 通讯作者: 袁子国

Research Progress of Interleukin-16

WU Song-ming1, ZHU Xing-quan1,2, YUAN Zi-guo1   

  1. 1. College of Veterinary Medicine,South China Agricultural University,Guangzhou 510642,China;2. State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China
  • Received:2010-11-21 Revised:1900-01-01 Online:2011-05-20 Published:2011-05-20

摘要: 白细胞介素-16是一种前炎症因子,由CD8T淋巴细胞分泌,属分泌型蛋白,过去称之为淋巴细胞趋化因子(lymphocyte chemoattractant factor,LCF),1995正式命名为白细胞介素-16(IL-16)。自从被克隆获得之后,其结构和功能得到广泛的研究,其生物学功能研究也取得了一定的进展。IL-16是多种免疫细胞的趋化因子,参与机体的炎症反应,还与过敏反应、自身免疫系统疾病等其他疾病有关。最近关于IL-16生物活性与临床疾病关系的研究成果比较多,文章对其结构、生物学功能、与疾病的关系及应用加以综述。

关键词: 白细胞介素-16; 生物学功能; 疾病; 应用

Abstract: Interleukin-16 is a kind of pro-inflammatory cytokines and secretory proteins,secreted by CD8T cell. Initially,it was described as lymphocyte chemoattractant factor,officially named as interleukin-16 in 1995. Since it’s cloned,its structure and function have been researched extensively, besides, there’s a certain study about its bioactivity. IL-16 is characterized as a chemoattractant for various immune cells,which plays a part in inflammation,allergy,autoimmune and other diseases. Recently,there is much research about the relationship between bioactivity and diseases. So according to current data,this review summarized IL-16 structure,biology function,the relationship between diseases and practical application.

Key words: interleukin-16; biology function; diseases; practical application

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